Microorganisms are important sources for screening bioactive natural products. However, natural products from deep-sea microbes have not been extensively explored. In this study, the metabolites of bacteriophage GVE2 -infected (Geobacillus sp. E263 virus) thermophilic bacterium Geobacillus sp. E263, which was isolated from a deep-sea hydrothermal vent, were characterized. A novel quinoid compou...

Millingtonia hortensis is widely distributed tree which belongs to Bignoniaceae family, commonly used as a folk medicine, having anti epileptic, antioxidant, antimicrobial, larvicidal and anticancer activities. In the present study, purification and characterization of bioactive compound(s) from methanolic extract of the leaves of Millingtonia hortensis were carried out using silica gel column ...

Bioactive compounds are often used as initial substances for many therapeutic agents. In recent years, both theoretical and practical innovations in hardware-assisted fast-evolving machine learning (ML) have made it possible to identify desired bioactive chemical spaces, such those natural products (NPs). This review introduces how approaches can be the identification evaluation of compounds. I...

The trend to search novel microbial natural biocides has recently been increasing in order to avoid the environmental pollution from use of synthetic pesticides. Among these novel natural biocides are the bioactive secondary metabolites of Burkholderia gladioli pv. agaricicola (Bga). The aim of this study is to determine antifungal activity of Bga strains against some phytopathogenic fungi. The...

Natural products with a sulfated scaffold have emerged as antifouling agents with low or nontoxic effects to the environment. In this study 13 sulfated polyphenols were synthesized and tested for antifouling potential using the anti-settlement activity of mussel (Mytilus galloprovincialis) plantigrade post-larvae and bacterial growth inhibition towards four biofilm-forming bacterial strains. Re...

Curcumin is a natural bioactive compound originated from the rhizomes of turmeric (Curcuma longa L.). This study was performed to investigate formic acid and microwave assisted extraction of curcumin from turmeric (Curcuma longa L.). In order to enhance the curcumin extraction, different parameters such as particle size, effect of pretreatment with water, radiation intensity and type of solvent...

A wound is a disruption of the normal anatomical structure and function of a tissue. Wounds cure in an orderly and timely repair process which is characterized by three dynamic and interactive phases: inflammation, proliferation and the remodeling. The present review was designed to elaborate the cellular and molecular targets for plant secondary metabolites that target the various aspects of w...

Abstract:Turmeric is a member of the ginger family (Zingiberaceae), which is extensively used as a spice, food preservative and colouring material. Curcumin is a main bioactive natural compound derived from the rhizome of this plant. Curcumin can exist in several tautomeric forms, keto and enol. The keto form is more stable than enol form. Silyl ethers have proven to be versatile substrates for...

Curcumin is a bioactive compound from turmeric which has different biological properties and health benefits such as antioxidant, anti-inflammatory, antimicrobial, and anticancer activities. However, the low solubility, poor bioavailability, and rapid degradation under neutral or alkaline pH conditions or when exposed to light, limit the food applications of curcumin. These problems can be solv...

marine streptomyces are prolific producers of majority of bioactive secondary metabolites which are used in pharmaceutical industry as effective drugs against life threatening diseases. the cytotoxic activity of the pure compound 1, 2- benzene dicarboxylic acid, mono 2- ethylhexyl ester (dmehe) from marine derived actinomycete streptomyces sp. vitsjk8 was investigated against mouse embryonic fi...