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Nonalcoholic fatty liver disease (NAFLD) is the most common cause of abnormal hepatic steatosis in the absence of a history of alcohol use. Nonalcoholic steatohepatitis (NASH) is the progressive form of NAFLD. Hyperhomocysteinemia causes steatosis, and the methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms result in hyperhomocysteinemia. To examine whether the C677T and ...

Among the most fundamental problems in Al-gorithmic Game Theory are those concerning the Nash equilibria of a strategic game: states where no player could unilaterally deviate to improve her utility. Such algorithmic problems, including their decision, search and approximation variants , have been studied extensively in the last few years. The fundamental theorem of Nash [4,5] that Nash equilib...

We studied the effects of exercise on muscle mitochondria, and lipid and glycogen content in nonalcoholic steatohepatitis (NASH) model rats. Male Sprague-Dawley rats were randomly separated into 3 groups: the control group was fed standard chow; the NASH group was fed a methioninecholine-deficient high-fat diet (MCD); the NASH-exercise group was fed the MCD and exercised three times a week. Exe...

Nash [13] introduced the concept of Nash equilibria in non-cooperative games and proved that any game possesses at least one such equilibrium. A well-known algorithm for computing a Nash equilibrium of a 2-player game is the Lemke-Howson algorithm [11], however it has exponential worst-case running time in the number of available pure strategies [15]. Recently, Daskalakis et al [4] showed that ...

We study extreme Nash equilibria in the context of a selfish routing game. Specifically, we assume a collection of n users, each employing a mixed strategy, which is a probability distribution over m parallel identical links, to control the routing of its own assigned traffic. In a Nash equilibrium, each user selfishly routes its traffic on those links that minimize its expected latency cost. T...

â  â  background non-alcoholic fatty liver disease/steatohepatitis (nafld/nash) is the most common form of chronic liver disease woldwide and is no longer considered a benign disease. its prevalence has not been deterâ­mined in a large-scale population-based study in iran. me t hod s a total of 6583 individuals aged 18 to 65 were randomly selected from three geographically distinct provinces in...

The aim of this study was to clarify the significance of DNA methylation alterations during non-alcoholic steatohepatitis (NASH)-related hepatocarcinogenesis. Single-CpG-resolution genome-wide DNA methylation analysis was performed on 264 liver tissue samples using the Illumina Infinium HumanMethylation450 BeadChip. After Bonferroni correction, 3331 probes showed significant DNA methylation alt...

Every real algebraic variety is isomorphic to the set of totally mixed Nash equilibria of some three-person game, and also to the set of totally mixed Nash equilibria of an N-person game in which each player has two pure strategies. From the Nash-Tognoli Theorem it follows that every compact differentiable manifold can be encoded as the set of totally mixed Nash equilibria of some game. Moreove...

Lack of exercise and excessive food intake are known to be the important causes of nonalcoholic steatohepatitis (NASH). To elucidate the relationship between lifestyle and NASH, we surveyed exercise and dietary habits, comparing them among 171 biopsy-proven NASH patients, 29 nonalcoholic fatty liver (NAFL) patients and 49 normal subjects. Dietary habits including the duration of dinner time, am...