© 2009 The Authors. doi: 10.2340/00015555-0685 Journal Compilation © 2009 Acta Dermato-Venereologica. ISSN 0001-5555 Sir, Acquired reactive perforating collagenosis (ARPC) is associated with diabetes mellitus and/or chronic renal failure. The disease lesions consist of many dome-shaped nodules, which have a central umbilication containing firm keratotic plugs. Histologically, transepidermal eli...

Narrow-band (312 nm) ultraviolet B light (UVB) is a new form of therapy for psoriasis, but its mechanism of action is unknown. In a bilateral comparison clinical study, daily exposure of psoriatic plaques to broad-band UVB (290-320 nm) or 312-nm UVB depleted T cells from the epidermis and dermis of psoriatic lesions. However, 312-nm UVB was significantly more depleting in both tissue compartmen...

Vitiligo is an acquired pigmentary disorder characterized by depigmentation of skin and hair. Melanocyte migration is an important event in re-pigmentation of vitiligo. We have demonstrated that narrow-band ultraviolet B (UVB) irradiation stimulated cultured keratinocytes to release a significant amount of basic fibroblast growth factor (bFGF). Furthermore, narrow-band UVB enhanced migration of...

Obviously, vitiligo is a multifactorial disease, and at this stage, we all accept that the autoimmune theory, the adhesion defect theory and the biochemical theory based on oxidative stress are the mainstays of our current knowledge about the aetiology of the disease. The presence of an imbalance in the anti-oxidant system in vitiligo melanocytes was assessed early, providing support for a free...

Pityriasis lichenoides is an uncommon, acquired, papulosquamous disorder that exhibits various clinical presentations, including acute, chronic, and febrile ulceronecrotic Mucha- abermann forms. Pityriasis lichenoides chronica (PLC) is the chronic form of this continuum. Its treatment is challenging for patients and clinicians and some cases are multidrug resistant. Today, this disorder has man...

normal 0 false false false en-us x-none ar-sa microsoftinternetexplorer4 background : vitiligo as a common pigmentary disorder affects up to 2% of the general population. there are several treatment modalities in the literature but photo therapy is one of the best known with an improving effect. the goal of this study was to compare the efficacy of nb-uvb alone with adjunction of nb-uvb with ne...