Case 1 A 69-year-old Caucasian male, suffering from NC since the age of 17, presented to us at the age of 64 years (in 2006). His history included EDS with sleep attacks, hallucinations, frequent cataplexy and occasional sleep paralysis. Patient’s psychomotor development was normal and clinical history unremarkable; in particular, he denied infectious or inflammatory cerebral diseases, head tra...

A 37 year old Chinese man suffered from coexisting narcolepsy and morbid jealousy which were precipitated by head injury 5 years previously. Fluoxetine 20 mg/day reduced his narcoleptic symptoms and morbid jealousy but not his sleepiness. On defaulting treatment, the patient's symptoms and marital problem recurred. A common central serotonin disturbance might be involved in mediating the sleep ...

STUDY OBJECTIVE To determine if the combination of scheduled sleep periods and stimulant medications were more effective than stimulant medications alone in controlling the excessive daytime sleepiness experienced by narcoleptic patients. DESIGN Twenty-nine treated narcoleptic subjects were randomly assigned to one of three treatment groups: 1) two 15-minute naps per day; 2) a regular schedul...

Narcolepsy is a sleep disorder characterized by excessive daytime sleepiness and rapid eye movement (REM) sleep-related symptoms, such as cataplexy. The exact pathophysiology underlying the disease is unknown but may involve central cholinergic systems. It is known that the brainstem cholinergic system is activated during REM sleep. Furthermore, REM sleep and REM sleep atonia similar to cataple...

OBJECTIVE To compare MSLT parameters in two groups of patients with daytime sleepiness, correlated to the occurrence and onset of dreams. METHOD Patients were submitted to the MSLT between January/1999 and June/2002. Sleep onset latency, REM sleep latency and total sleep time were determined. The occurrence of dreams was inquired following each MSLT series. Patients were classified as narcole...

that narcoleptic dogs have mutations in one of the hypoIn the 2⁄2 years since hypocretin (also called orexin) was cretin receptors, the hypocretin receptor 2 (orexin 2 refirst described (de Lecea et al., 1998; Sakurai et al., ceptor) (Lin et al., 1999). Although different mutations 1998), more than 120 papers on the peptide have already were found in each of two narcoleptic breeds of dogs, been...

P1730 NO NORMALIZATION OF HYPOCRETIN-1 DEFICIENCY OR NARCOLEPTIC PHENOTYPE AFTER EARLY IVIG TREATMENT IN POST-H1N1 VACCINATION NARCOLEPSY WITH CATAPLEXY S. Knudsen1, B. Biering-Sørensen2, J.D. Ibsen1, E.R. Petersen1, S. Gammeltoft3, P. Jennum1 1Danish Center for Sleep Medicine, Department of Clinical Neurophysiology, 2Department of Neurology, 3Department of Clinical Biochemistry, University of ...