Introduction: The HDAC inhibitors are important drugs for the treatment of PTCL. While these produce ORR 25–30% with short PFS, responses can last over a year. There is still debate on optimal ways to use inhibitors. Most oral prolonged AUC exposure. Romidepsin (R) administered IV and exhibits half-life only 3 hours, though biological effects chromatin may persist 24–48 hours. A failed Phase 4 ...

Superior operating safety with long cycle life and lowmaterial cost makes lithium iron phosphate (LiFePO4) an important Li storage material. For this olivine compound, many efforts have been expended in order to achieve desirable electrochemical properties such as particle nanosizing and applying electrically conductive coating. However, these processes reduce tap density and therefore lower pr...

Research and development on food applications of nanoscale science has been growing worldwide and, although nanostructures are not a new phenomenon in our diet, it is now possible to characterise them much better than before due to marked technological advances, for example in electron microscopy, and this is at least one reason for their recently raised profile on the scientific horizon. Nanot...

DOI: 10.1002/aenm.201501590 electrochemical stability window, and (3) chemical compatibility with the anode and cathode. In the past few years, major advances have been achieved in increasing the Li ionic conductivity of the solid electrolytes. The state-of-the-art solid electrolyte materials, such as Li-garnet Li7La3Zr2O12 (LLZO) and Li10GeP2S12 (LGPS) have achieved an ionic conductivity of 10...

Simvastatin is a poorly water-soluble drug, and bioavailability from its crystalline form is very low. The purpose of this investigation was to increase the solubility and dissolution rate of simvastatin by the preparation of nanosuspensions with Pluronic F127 and zirconium oxide (ZrO2) beads using a wet-milling technique at the laboratory scale. Prepared nanosuspensions were evaluated for part...

In this report, we describe our work towards high performance lithium ion batteries through self-healing polymer approach. In this initial stage of the project, we first design and synthesis a series of self-healing polymers with different mechanical properties and self-healing capabilities. Further comparison of the battery cycling will give a deeper understanding of the relationship between p...