INTRODUCTION The ongoing surge of resistance of bacterial pathogens to antibiotic therapies and the consistently aging median member of the human race signal an impending increase in the incidence of chronic bone infection. Nanotechnological platforms for local and sustained delivery of therapeutics hold the greatest potential for providing minimally invasive and maximally regenerative therapie...

Sodium-dependent calcium exchange may be an important mediator of calcium reperfusion damage during the calcium paradox phenomenon. We measured intracellular sodium activity with ion-selective electrodes during a 15-min period of calcium reperfusion in isolated ferret papillary muscles. During the calcium-free period, alpha Nai increased from 9.0 +/- 0.9 to 18.9 +/- 4.3 mM. With reinstitution o...

ABSTRACT Objective To describe the prevalence of inadequate mineral intake and associated factors with calcium, iron, zinc, magnesium, phosphorus, sodium intakes in individuals aged 15-24.9 years. Methods We analyzed 476 from Brazilian Study Nutrition Health, stratified into two age groups (adolescents 15-18.9 years young adults 19-24.9 years). Mineral was obtained 24-hour Dietary Recalls. The ...

Orai1 interacts with transient receptor potential protein of the canonical subfamily (TRPC4) and contributes to calcium selectivity of the endothelial cell store-operated calcium entry current (ISOC). Orai1 silencing increases sodium permeability and decreases membrane-associated calcium, although it is not known whether Orai1 is an important determinant of cytosolic sodium transitions. We test...

expansive soils are considered a worldwide problem as they cause extensive damage tocivil engineering structures. an important characteristic of expansive soils is theirsusceptibility to volume change due to the phenomenon of wetting and drying. this paperpresets the effect of pore water quality on the swelling and shrinkage behavior of anexpansive soil during wetting and drying cycles. thirty ...

Background: The present study aimed to investigate the prevalence of electrolyte imbalance in hypoxic-ischemic encephalopathy (HIE). Moreover, the correlation of this condition with Apgar score is evaluated. Methods: This prospective observational hospital-based study was conducted on 75 neonates affected by asphyxiation. Immediately (within ...

Several studies have shown an increase in urinary calcium excretion in response to a calcium load. However, because of the inverse changes in PTH levels with a calcium load, the effect of changes in serum calcium per se on its own excretion is unclear in humans. In this study we used a PTH clamp protocol to further characterize calcium-regulated renal calcium and magnesium handling and the rela...