Toxoplasma gondii is deemed a successful parasite worldwide with wide range of hosts. Currently, combination pyrimethamine and sulfadiazine serves as the first-line treatment; however, these drugs have serious adverse effects. Therefore, it imperative to focus on new therapies that produce desired effect lowest possible dose. The designation synthesis sulfonamide-1,2,3-triazole hybrids (3a–c) w...

INTRODUCTION: Curcuminoids and Oleic acid, reported in the literature as antioxidant antitumor agents, were combined nanoemulsion, using Pluronic F127 a stabilizer.
 METHODS: The main objective is to investigate its cytotoxic activity against cancer cells.
 RESULTS AND DISCUSSION: nanoemulsion show values of particle size (251.4 ± 4.6 nm), zeta potential (-34.8 1.0 mV), pH (4.8) class...

In this study, an anti-oxidant nanoformulation to prevent the oxidation of salmon was developed using rosmarinic acid (RA). Minced samples (MSs) were treated with 8.10-3 g (RAT1) and 16.10-3 (RAT2) RA-loaded nanoparticles for 100 MS acid, separately. The thiobarbituric (TBA) values control (C), RAT1, RAT2 stored at 4 °C found as 2.995, 1.350, 0.994 mg MDA/kg; respectively, after 9 days. While i...

Benign prostatic hyperplasia (BPH) is the most common age-related disease in men. Here we tested the efficacy of Rapatar, a micellar nanoformulation of rapamycin, in two rat models of BPH: testosterone-induced and sulpiride-induced hyperplasia in ventral lobes and lateral/dorsal lobes, respectively. We found that Rapatar prevented hypertrophic and hyperplastic abnormalities and degenerative alt...

AIM This study aimed to develop a new stable nanoformulation of silymarin (SM) with optimum enhanced oral bioavailability and to evaluate its effect as well as mechanism of action as a superior antidiabetic agent over native SM using streptozotocin-induced diabetic rats. MATERIALS AND METHODS SM-loaded pluronic nanomicelles (SMnp) were prepared and fully characterized. Biochemical parameters ...

In HIV-1 management, eradication of the virus from sanctuaries represents a major and challenging goal. The genital tract, gut associated lymphoid tissue, lymph nodes, central nervous system, macrophages and latently infected CD4+ T lymphocytes are typical sites where HIV-1 compartmentalizes. To circumvent this problem, a consistent number of studies have focused on improving ARVs (antiretrovir...