The aim of this study was to evaluate (+)-catechin and (-)-epigallocatechin gallate (EGCG) cellular uptake and transport across human intestinal Caco-2 cell monolayer in both the absence and presence of niosomal carrier in variable conditions. The effect of free drugs and drug-loaded niosomes on the growth of Caco-2 cells was studied. The effects of time, temperature, and concentration on drug ...

niosomes are non-ionic surfactant vesicles that have potential applications in the delivery of hydrophilic and hydrophobic drugs. the topical form of n-acetyl glucosamine (nag) recently has been considered in the treatment of hyperpigmentation disorders due to its inhibitory effect on thyrosinase enzymes in melanocytes. to improve nag penetration into the skin we formulated the drug in niosomes...

The aim of the present investigation is to encapsulate rofecoxib in niosomes and incorporate the prepared niosomes into dermal gel base for sustained therapeutic action. Niosomes were prepared by lipid film hydration technique and were analyzed for size, entrapment efficiency and drug retention capacity. Niosomal vesicles were then incorporated into blank carbopol gel to form niosomal gel. The ...

The objective of the present study was to prepare a stable iv injectable formulation of ascorbic acid and α-tocopherol in preventing the cerebral ischemia. Different niosomal formulations were prepared by Span and Tween mixed with cholesterol. The physicochemical characteristics of niosomal formulations were evaluated in vitro. For in vivo evaluation, the rats were made ischemic by middle cereb...

Niosomes have been reported as possible approach to improve the low corneal penetration and bioavailability characteristics for many drugs. The purpose of this study was to prepare and characterize an effective ocular niosomal hydrogel containing 0.5% (w/v) atenolol which is β1 adrenoceptor blocker for treatment of glaucoma. Thin film hydration method was used for the preparation of niosomes us...

This study evaluated the cellular uptake and cytotoxicity of low permeable Ursolic acid (UA) on cancer cells using niosomes composed span 60 cholesterol. The results showed that addition chitosan increased particle sizes ζ-potentials. UA with layers had higher in HeLa than without chitosan, however, there was no improvement observed for Huh7it cells. Moreover, improved uptake, which clathrin-me...

Conveying the therapeutic agent to human eye has been a struggling task for formulators and scientists because of complicated arrangement eye. The agents needed deliver drugs specific sites require crossing various ocular barriers, which act as hitches drug delivery. Conventional preparations present in market do not achieve desired results due their lower bioavailability, less retention time, ...

Objective: The primary goal of this study was to develop a topical gel containing tramadol hydrochloride-loaded Niosomes injection technique as the vesicular carrier for site-specific delivery. Methods: niosomes were created by varying ratios nonionic surfactants (Tween 80, Tween 60, 20, Span and 80) cholesterol while keeping drug concentration constant. Results Discussion: Each formulation exa...