magnetite (fe 3 o 4  and nio) nanoparticles with a size range of 40–60 nm were prepared by sol-gel technique in nano and micro reverse micelles (water- in-oil). the surface properties, size, morphology and crystallographic structure of fe 3 o 4 and nio particles are characterized by means of x-ray diffraction, transmission electron microscope and scanning electron microscope which will give muc...

Superparamagnetic iron oxide nanoparticles (SPION) are an important and versatile nano- platform with broad biological applications. Despite extensive studies, the biological and pharmacological activities of SPION have not been exploited in therapeutic applications. Recently, β-lapachone (β-lap), a novel anticancer drug, has shown considerable cancer specificity by selectively increasing react...

This paper reports on synthesis of hollow spheres of magnetite, guided by micelles and their application in drug release by the stimulus responsive technique. Here oleyelamine micelles are used as the core substance for the formation of magnetite nano hollow spheres (NHS). Diameter and shell thickness of NHS have been changed by changing concentration of the micelles. Mechanism of NHS formation...

This study was carried out to investigate an effective method for the co-delivery of Gemcitabine (GEM) and paclitaxel (PTX) into tumor cells. GEM and PTX were modified with functional (+)-a-tocopherol (VE) to obtain similar water solubility. Folic acid-poly(ethylene glycol)–(+)-a-tocopherol (FA–PEG–VE) was designed to co-encapsulate the modified GEM and PTX. Methoxy poly(ethylene glycol)–poly(l...

Alkynyl-terminated double hydrophilic ABC triblock copolymer, poly(oligo(ethylene glycol) monomethyl ether methacrylate)-b-poly(2-(dimethylamino) ethyl methacrylate)-b-poly(2(diethylamino) ethyl methacrylate) (alkynyl-POEGMA-b-PDMA-b-PDEA), was synthesized via atom transfer radical polymerization (ATRP) by sequential monomer addition using propargyl 2-bromoisobutyrate (PgBiB) as the initiator. ...

The therapeutic effect of methotrexate (MTX)-conjugated Pluronic-based polymeric mixed micelles (F127/P105-MTX) on the folate receptor-overexpressing tumors treatment was investigated in this study. Due to its high structural similarity to folic acid and the high expression of folate receptor in most solid tumors, MTX serves as not only a cytotoxic agent but also a homing ligand. Cellular uptak...

Nano particle formulations, especially protein based formulations are great drug delivery systems for a targeted and sustained drug release. The Specificity lies with the receptor-ligand binding mechanism adopted by them. Metformin hydrochloride (MET) is a widely used biguanide oral antidiabetic agent, against Type II diabetes. In its free form, it suffers some shortcomings like poor oral bioav...

We report a polymeric micelle drug delivery system, which enables selective intracellular uptake with external thermal stimulation, and effective release of a drug at internal acidic endosomal pH. We developed a dual temperatureand pH-responsive polymeric micelle composed of a temperatureresponsive corona segment with poly(N-isopropylacrylamide-co-dimethylacrylamide) [P(NIPAAm-coDMAAm)] and a p...

Amphiphilic block copolymer micelles have been the focus of research for the last decades because of the promising properties as nano size drug delivery vehicles. In polar aqueous milieu, copolymers self assemble into micelle structures which consist of hydrophilic corona and hydrophobic core regions. Space created inside the micelle core can be used for transportation of drug molecules of hydr...