نتایج جستجو برای: naloxone withdrawal syndrome
تعداد نتایج: 649642 فیلتر نتایج به سال:
Background & Objective : Chronic morphine consumption has a profound disturbing effect on central nervous system cased morphine dependence. Regarding to low efficacy of chemical drugs for relief of addiction, and with respect to recommendation of medicinal plant in new therapeutic medicine we use a most candidate herb Datura stramonum for this purpose. Materials & Methods: Animals were addi...
Received: 6 Aug, 2008 Accepted: 14 Jan, 2009 Abstract: Background & aims: Drug abuse and dependence have been focused by many physicians until now. Many approaches were used for cessation of withdrawal syndrome but pharmaceutical agents were used widely. Magnetic fields were used for treatment or decreasing some disorders such as pain. Some studies have shown that magnetic fields can affect ...
Introduction: Recently, it has been demonstrated that olive leaf extract and its main component have calcium channel blocker, anti-inflammatory and anti-oxidative properties. However, the effects of olive leaf extract on opioid dependence have not yet been clarified. Methods: To develop morphine dependence, morphine was injected twice daily for 7 days according to an escalating dose in rats...
Background and Objective: Locus coeruleus (LC) has been hypothesized to play an important role in a variety of behaviors and opiate withdrawal. This study was designed to determine the effects of reversible inactivation of LC on self-administration of morphine and morphine- withdrawal syndrome signs (MWS). Materials and Methods: 24 male rats (250-300gr) were surgically implanted bilaterally wit...
The effects of opiate dependence and antagonist-precipitated withdrawal on glucocorticoid (GR) and mineralocorticoid (MR) receptor mRNA levels in the rat brain were studied. Rats were allocated to one of four groups that differed in terms of type of drug pretreatment (morphine pellet versus placebo pellet) and type of injection on test (naloxone versus no injection). Injection of naloxone preci...
In the present study, interactive effects of D1 and D2 dopamine receptors antagonists and different periods of lithium pretreatment on morphine dependence in mice have been investigated. This study was designed to investigate whether the hypothesis that lithium and dopaminergic mechanisms via their effects on phosphoinositide pathways and calcium flux could influence morphine withdrawal respons...
In this study using clonidine (a mixed ?2 /I1 receptors agonist), tizanidine (pure ?2-receptor agonist), rilmenidine (I1 receptor agonist) and yohimbine (?2-receptor antagonist), we tried to clarify the role of imidazoline and ?2-receptors in morphine withdrawal syndrome. Morphine-dependence was induced by administration of increasing doses of morphine in mice. After the last administration of ...
In this study using clonidine (a mixed ?2 /I1 receptors agonist), tizanidine (pure ?2-receptor agonist), rilmenidine (I1 receptor agonist) and yohimbine (?2-receptor antagonist), we tried to clarify the role of imidazoline and ?2-receptors in morphine withdrawal syndrome. Morphine-dependence was induced by administration of increasing doses of morphine in mice. After the last administration of ...
The present study was conducted to investigate the effect of potassium channel openers and blockers on morphine withdrawal syndrome. Mice were rendered dependent on morphine by subcutaneous injection of morphine; four hours later, withdrawal was induced by using an opioid antagonist, naloxone. Mice were observed for 30 minutes for the withdrawal signs ie, the characteristic jumping, hyperactivi...
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