BACKGROUND Severe metabolic acidosis occurs during orthotopic liver transplantation (OLT) particularly during the anhepatic phase. Although NaHCO3 is considered as the current standard therapy, there are numerous adverse effects. The aim of this study was to determine whether the restricted use of normal saline during anesthesia could reduce the need for NaHCO3. METHODS In this study we enrol...

Isometric, electrically paced strips of cardiac ventricle from two species of fish (plaice, Pleuronectes platessa; cod, Gadus morrhua) with different tolerance to hypoxia were compared with respect to effects of hypercapnic acidosis. Acidosis was induced by altering the equilibrating gas mixture for the muscle strip chamber from 3% CO2 in 97% 02 to 15% CO2 in 85% O2. The pH was varied further b...

Gavage of 2 M NaCl (IG 2 M NaCl), a procedure to induce cell-dehydration-and water and 0.15 M NaCl intake in a two-bottle choice test-is also a potential gastric irritant. In this study, we assessed whether mineral intake induced by IG 2 M NaCl is associated with gastric irritation or production of pica in the rat. We first determined the amount of mineral solution (0.15 M NaCl, 0.15 M NaHCO3, ...

Kentos adalah bagian dari kelapa yang terdapat di dalam buah sudah tua. ini merupakan cikal bakal tunas seringkali hanya terbuang sebagai limbah. Pada penelitian ini, kentos dimanfaatkan menjadi cemilan bernama fried coconut sprout. Tujuan menjadikan limbah makanan disukai oleh semua lapisan masyarakat. Hasil menunjukkan bahwa sprout dihasilkan panelis secara organoleptik, yaitu segi rasa, warn...

Alkali therapy may limit the progression of chronic kidney disease (CKD)1Gianella F.G. Prado V.E. Poindexter J.R. et al.Spot urinary citrate-to-creatinine ratio is a marker for acid-base status in disease.Kidney Int. 2021; 99: 208-217Abstract Full Text PDF PubMed Scopus (18) Google Scholar, 2Goraya N. Simoni J. Sager L.N. Madias N.E. Wesson D.E. Urine citrate excretion as acid retention patient...

BACKGROUND Angiotensin II (AII) mediates glomerular filtration rate (GFR) decline in animals with subtotal nephrectomy (Nx), but the mechanisms for increased AII activity are unknown. Because reduced GFR of Nx is associated with acid (H(+)) retention that increases kidney AII, AII-mediated GFR decline might be induced by H(+) retention. METHODS We measured GFR and kidney microdialyzate H(+) a...

This study examined the acute effects of NaHCO3 ingestion on repetitions to failure and rating of perceived exertion in the back squat and bench press in trained men. Eight resistance-trained men took part in this double-blind, randomized crossover experimental study whereby they ingested NaHCO3 (0.3 g·kg(-1) body mass) or placebo (sodium chloride NaCl: 0.045 g·kg(-1) body mass) solution 60 min...

The mechanisms governing maintenance of quiescence during pregnancy remain largely unknown. The current study characterizes a stretch-activated, tetraethylammonium-insensitive K(+) current in smooth muscle cells isolated from pregnant human myometrium. This study hypothesizes that these K(+) currents can be attributed to TREK-1 and that upregulation of this channel during pregnancy assists with...

in order to determine the best growing media for gerbera jamesonii under alkaline conditions, a factorial experiment was conducted with two factors, namely: (i) growing medium, and (ii) concentrations of bicarbonate (nahco3) in nutrient solution. results showed that increasing the concentration of nahco3 from 0 to 40 mm in nutrient solution significantly decreased plant growth, maximal quantum ...