Two major issues which hamper the use of the anticancer drug cisplatin are the development of cancer cell resistance and its nephrotoxicity. One possible mechanism by which resistance is reported to develop is a reduction in drug uptake across the cell membrane. While the passive uptake of cisplatin has long been cited as an important contribution, far greater attention has been given to active...

the high CISs found only in the PLX4720-resistant tumors. Further characterization revealed four transposon sites in the first intron of ERAS, with an integration pattern signifying gene activation. The PLX4720-resistance conferring phenotype was confirmed in human melanoma cell lines ectopically expressing ERas. Further mechanistic studies revealed that ERAS inactivation of BAD (BCL2-associate...

The development of ever more efficient hardware and software has allowed for the simulation of complex biological systems, such as that of a large protein, in atomistic detail on the timescale of up to around a microsecond. This is enough to observe biologically significant conformational changes driven by complex combinations of thermally induced perturbations to single atoms that make up the ...

objective: the use of antiretroviral drugs has proven remarkably effective in controlling the progression of human immunodeficiency virus (hiv) disease, but these benefits can be compromised by the development of drug resistance. this study aims to assess the drug resistance profile of the pr gene in highly active antiretroviral therapy (haart)-treated and naïve hiv-1 infected patients. metho...

objectives in this study, we explored a physical method of converting drug-resistant bacteria to drug-sensitive ones. materials and methods this is an in vitro case-control study, performed at the ionizing and non-ionizing radiation protection research center (inirprc), shiraz university of medical sciences (sums), shiraz, iran in 2014. all experiments were carried out using gram-negative bacte...

conclusions these findings underscored the importance of monitoring and developing guidelines for better management of infectious diarrhoea in bangladesh and elsewhere. background diarrhoea is considered as the most widespread illness occurring in bangladesh. in addition, the growing antimicrobial resistance of diarrhoeal pathogens in this developing country hardens physicians to supervise pati...

Combination chemotherapy is standard for metastatic colorectal cancer; however, nearly all patients develop drug resistance. Understanding the mechanisms that lead to resistance to individual chemotherapeutic agents may enable identification of novel targets and more effective therapy. Irinotecan is commonly used in firstand second-line therapy for patients with metastatic colorectal cancer, wi...

extensively drug-resistant tuberculosis (xdr-tb) is a new challenge for tuberculosis control programs. lack of effective drugs and high rate of failure in treatment and mortality is a major threat for public health. treatment of this serious infection needs well-designed individualized dosage regimen and powerful national tb program. in this review we will describe the xdr-tb definition and its...

Neuraminidase (NA) inhibitors are the dominant antiviral drugs for treating influenza in the clinic. Increasing prevalence of drug resistance makes the discovery of new NA inhibitors a high priority. Thirty-one triterpenoids from the medicinal mushroom Ganoderma lingzhi were analyzed in an in vitro NA inhibition assay, leading to the discovery of ganoderic acid T-Q and TR as two inhibitors of H...