The intrinsically disordered 18.5 kDa classic isoform of MBP (myelin basic protein) interacts with Fyn kinase during oligodendrocyte development and myelination. It does so primarily via a central proline-rich SH3 (Src homology 3) ligand (T92-R104, murine 18.5 kDa MBP sequence numbering) that is part of a molecular switch due to its high degree of conservation and modification by MAP (mitogen-a...

Aims. To investigate candidates for Be/X-ray binaries in the Small Magellanic Cloud (SMC), we observed a region around the emission nebula N19 with XMM-Newton in October 2006. Methods. We analysed the EPIC data of the detected point sources to derive their spectral and temporal characteristics. Results. We detected X-ray pulsations with a period of 25.550(2) s from the second-brightest source i...

In 2004, sugarcane thrips Fulmekiola serrata (Kobus) (Thysanoptera: Thripidae) was for the first time detected in southern African sugarcane. Since then it has become widespread in South Africa, and any control strategy would benefit from identifying and monitoring damage caused by this pest. Imaging spectroscopy is being investigated for this purpose, and is used in conjunction with space-born...

To determine the molecular mechanisms of aggressive prostate cancer behavior, we studied RhoGTPases in high and low invasive variants of PC-3 prostate cancer cells. Prior studies with these cells revealed that elevated nuclear factor B (NFB) expression and activity were necessary for the highly invasive phenotype. In the current study, increased RhoA expression was found in the PC-3 highly inva...

Ditch samples from AP-4, ER-51 and UK-2 offshore Niger Delta were subjected to biostratigraphic organic geochemical analyses which entail foraminiferal, palynological, Spore Colour Index (SCI), Rock-Eval Pyrolysis Fourier Transform Infrared Spectroscopy (FTIR) analyses. The results have established N19 N17; N17, N16 N15; N9 N8 biozones; P600 P700 palynological zones. dominance of palynomaceral ...

Sustainable sugarcane production in areas prone to frequent and severe drought can be achieved by creating resilient varieties. In this study, a unique mutant line, M9.2, was generated from susceptible commercial cultivar, N19, through the exposure of callus cells ethyl methanesulfonate mutagen subsequent vitro osmotic selection on polyethylene glycol. The study aimed characterise M9.2 mutant, ...

Abstract Background and Aims Little is known about trends over time anticipated improvements in CKD diagnosis after the implementation of Kidney Disease – Improving Global Outcomes (KDIGO) guidelines 2012. We investigated prevalence incidence using claims data persons aged 70+. Method assessed biennially cross-sectional German health insurance fund “AOK Nordost” for 70+ between 2012 2018. Data ...