PURPOSE To investigate how neuronal nitric oxide synthase (nNOS) contributes to regulation of the retinal circulation during rest and flicker stimulation in cats. METHODS Using laser Doppler velocimetry, we measured the vessel diameter and blood velocity simultaneously and calculated the retinal blood flow (RBF) in feline first-order retinal arterioles. After intravitreal injections of Nω-Nit...

The aim of the present study is to investigate the effect and potential mechanism of action of 6-gingerol on alterations of vascular reactivity in the isolated aorta from diabetic rats. Male Wistar rats were divided into two experimental groups, control and diabetics. Diabetes was induced by a single intraperitoneal injection of streptozotocin (50 mg kg(-1)), and the rats were left for 10 weeks...

Hypertension is a chronic disease affecting the whole world due to its clinical effects and complications. The reduction in release effect of NO one mechanisms hypertension formation. disrupts balance between oxidant antioxidant mechanisms. In this study, we aimed observe biochemical changes blood by treatment propolis, caffeic acid phenethyl ester (CAPE) pollen hypertensive rats via Nω-Nitro-L...

Learning mixtures of k binary product distributions is a central problem in computational learning theory, but one where there are wide gaps between the best known algorithms and lower bounds (even for restricted families of algorithms). We narrow many of these gaps by developing novel insights about how to reason about higher order multilinear moments. Our results include: (1) An nO(k 2) time ...

We consider the computational complexity of determining whether an Erdős-Rényi random graph contains a subgraph isomorphic to a fixed pattern, such as a clique or cycle of constant size. We give an overview of unconditional lower bounds for this problem, focusing on circuits and formulas in the AC 0 and monotone settings. 1 Background and preliminaries The subgraph isomorphism problem is the co...

The small GTPase RhoA and its associated kinase ROCKII are involved in vascular smooth muscle cell contraction and endothelial NO synthase mRNA destabilization. Overactivation of the RhoA/ROCKII pathway is implicated in several pathologies, including chronic heart failure (CHF), and may contribute to the enhanced sympathetic outflow seen in CHF as a result of decreased NO availability. Thus, we...

Polyamine synthesis from l-ornithine is essential for Leishmania growth. We have investigated the dependence of Leishmania infection on arginase, which generates l-ornithine, in macrophages from BALB/c, C57BL/6, and nitric oxide synthase II (NOS II)-deficient mouse strains. We have found that N(omega)-hydroxy-l-arginine (LOHA), a physiological inhibitor of arginase, controls cellular infection ...

Nine toroidal field (TF) coils have been developed in Japan for the international thermonuclear experimental reactor (ITER). The joint resistance of TF coil should satisfy requirement smaller than 3 nano-ohm at 2 T external magnetic and 68 kA transport current. Full-size sample (FSJS) tests were performed development manufacture, as part process control. 11 FSJS are conducted total. with assist...