نتایج جستجو برای: myopathy

تعداد نتایج: 12241  

Journal: :The New England journal of medicine 2008
E Link S Parish J Armitage L Bowman S Heath F Matsuda I Gut M Lathrop R Collins

BACKGROUND Lowering low-density lipoprotein cholesterol with statin therapy results in substantial reductions in cardiovascular events, and larger reductions in cholesterol may produce larger benefits. In rare cases, myopathy occurs in association with statin therapy, especially when the statins are administered at higher doses and with certain other medications. METHODS We carried out a geno...

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Journal: :American heart journal 2010
Soko Setoguchi John M Higgins Helen Mogun Vamsi K Mootha Jerry Avorn

BACKGROUND A recent large-scale, chemical screening study raised the hypothesis that propranolol may increase the risk of myopathy. We tested this hypothesis in a large population to assess whether (1) propranolol use is associated with an increased risk of myopathy and (2) the concurrent use of propranolol with a statin may further increase risk of myopathy. METHODS New users of propranolol ...

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Journal: :Proceedings of the Royal Society of Medicine 1913

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Journal: :Journal of Neurology, Neurosurgery & Psychiatry 1979

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Journal: :BMJ 1969

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2018
Zhiyv Niu Carly Sabine Pontifex Sarah Berini Leslie E. Hamilton Elie Naddaf Eric Wieben Ross A. Aleff Kristina Martens Angela Gruber Andrew G. Engel Gerald Pfeffer Margherita Milone

Objective The aim of this study is to identify the molecular defect of three unrelated individuals with late-onset predominant distal myopathy; to describe the spectrum of phenotype resulting from the contributing role of two variants in genes located on two different chromosomes; and to highlight the underappreciated complex forms of genetic myopathies. Patients and methods Clinical and labo...

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2012
Clemens Neusch Tanja Kuhlmann Wolfram Kress Christiane Schneider-Gold

INTRODUCTION Miyoshi myopathy, a type of distal myopathy with predominant involvement of the posterior calf muscles, has been assigned to mutations in the dysferlin gene. However, many of the late-onset limb-girdle and distal myopathies that resemble dysferlinopathy or Miyoshi myopathy remain unclassified, even after extensive immunohistological and genetic analysis. CASE PRESENTATION We repo...

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Journal: :Gut 1993

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Journal: :Neurology India 2008
Chieko Fujimura-Kiyono Gabor Z Racz Ichizo Nishino

The term congenital myopathy is applied to muscle disorders presenting with generalized muscle weakness and hypotonia from early infancy with delayed developmental milestones. The congenital myopathies have been classified into various categories based on morphological findings on muscle biopsy. Although the clinical symptoms may seem homogenous, the genetic basis is remarkably variable. This r...

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2009
Tina Wenz Francisca Diaz Dayami Hernandez Carlos T. Moraes

Wenz T, Diaz F, Hernandez D, Moraes CT. Endurance exercise is protective for mice with mitochondrial myopathy. J Appl Physiol 106: 1712–1719, 2009. First published March 12, 2009; doi:10.1152/japplphysiol.91571.2008.—Defects in the mitochondrial ATP-generating system are one of the most commonly inherited neurological disorders, but they remain without treatment. We have recently shown that mod...

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