Anaphylaxis is an acute, severe systemic allergic reaction that can be potentially fatal. It often transition to refractory hemodynamic instability (new onset myocardial dysfunction/ left ventricular dysfunction/LVD). Stress-related cardiomyopathy (SRC) now emerging as a significant contributor of dysfunction and has multifactorial etiologies, including the excessive catecholamine released in i...

Sepsis-induced myocardial dysfunction (SIMD) is a common complication with high incidence rates in sepsis patients. This study aimed to investigate the roles of miR-210-3p regulating cardiomyocyte apoptosis and mitochondrial associated SIMD pathogenesis.

Both intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) have been implicated in neutrophil-mediated lung and liver injury during sepsis. However, the role of these adhesion molecules as well as the contribution of neutrophils in myocardial dysfunction during sepsis remains to be determined. The purpose of this study was to examine the role of ICAM-1, VCAM-...

There are few reports concerning interferon induced myocardial dysfunction. A known case of multiple myeloma who was receiving interferon alpha (IFA) for 14 months was brought to the emergency room in frank: pulmonary edema. After treatment of heart failure and discontinuation of interferon alpha, he remained asymptomatic thereafter. Another case of chronic active hepatitis on IFA complain...

A close link between heart failure (HF) and systemic insulin resistance has been well documented, whereas myocardial insulin resistance and its association with HF are inadequately investigated. This study aims to determine the role of myocardial insulin resistance in ischemic HF and its underlying mechanisms. Male Sprague-Dawley rats subjected to myocardial infarction (MI) developed progressiv...

background: longer survival after the total repair of the tetralogy of fallot increases the importance of late complications such as right ventricular dysfunction. this is a prospective study of the right ventricular function in totally corrected tetralogy of fallot patients versus healthy children. methods: thirty-two healthy children were prospectively compared with 30 totally corrected tetra...

Introduction: Cardiac remodeling after myocardial infarction, is associated with progressive ventricular dysfunction and cardiovascular death. The purpose of this study was to examine the effect of endurance exercise training on morphological changes in rat heart tissue following experimental myocardial infarction. Materials and methods: Rats used in this experiment (8-10 weeks old, 235 &p...

background: diabetes mellitus is capable of impairing the myocardial function. several studies have documented the influential impact of diabetes mellitus on the left ventricular function. the right ventricular function plays a significant role in the overall myocardial contractility; hence, this study was undertaken to evaluate the effect of diabetes mellitus type ii on the right ventricular f...

Introduction Epstein-Barr  virus  (EBV)  infection  can  present  with  a  variety  of  manifestation. Case Report  Here  we  present  a  case  of  a  7  year- old  immunocompetent  girl  who  came  with  acute  abdominal  pain ,  had  echocardiographic  evidence  of  myocardial  dysfunction  and  finally  was  diagnosed  as  a  case  of  serologically  proven  acute  EBV  infection. Conclusion...

Myocardial dysfunction contributes to the high mortality of patients with endotoxemia. Although nitric oxide (NO) has been implicated in the pathogenesis of septic cardiovascular dysfunction, the role of myocardial NO synthase 3 (NOS3) remains incompletely defined. Here we show that mice with cardiomyocyte-specific NOS3 overexpression (NOS3TG) are protected from myocardial dysfunction and death...