The possibility of surgical repair of fetal anomalies in utero has long tantalized obstetricians and pediatric surgeons, especially since the development of high-resolution real-time ultrasonography. The presumption has been that earlier in utero repair would provide superior outcomes for the offspring than would postnatal surgery. However, postnatal treatment is much simpler and is not traumat...

1016 May 2013 A FTER decades of preparing the theoretical framework of fetal surgery,1 the reality of it finally hit home in 2011 when Adzick et al. published their National Institutes of Health-supported study on outcomes after in utero surgery for myelomeningocele. Aptly named MOMS (Management of Myelomeningocele Study), the investigators terminated enrollment early after demonstrating that c...

Open Myelomeningocele-Mawdsley et al. MEDUBARL1TURNrm compared with those of a series of unoperated children reported from South Wales. Myelomeningocele is a relatively common anomaly, the surgical attitude to which has changed over the past few years to a more active approach. This has been encouraged by advances in the general management of paraplegia and its complications and the more succes...

BACKGROUND Difficulties with ambulation in patients with myelomeningocele often lead to physical inactivity, osteoporosis, and subsequent development of pathologic fractures. OBJECTIVE The purpose of this study was to examine bone mineral density and biochemical markers of bone metabolism in patients with myelomeningocele. DESIGN AND METHODS A total of 35 patients between 6 and 19 years of ...

be absent, prophesied its usefulness for selective insect control. The structures of two natural juvenile hormones from the Cecropia silkmoth, as substituted terpene derivatives, were finally reported in 1967 and 1968. This opened a frenzy of activity in juvenile hormone research involving the synthesis and testing of innumerable JH analogs and mimics. This volume, representing the proceedings ...