نتایج جستجو برای: myeloid leukemia
تعداد نتایج: 302085 فیلتر نتایج به سال:
Chronic myeloid leukemia is a ph-positive myeloproliferative disease, which usually manifested by hyperleukocytosis and massive splenomegaly. rare in childhood adolescence, it accounts for 2 to 3 % of all leukemias cases. priapism manifestation chronic an urgent urological condition that requires timely treatment prevent long-term complications, particular, erectile dysfunction.This review pres...
Acute myeloid leukemia is not a single disease but a group of neoplastic disorders. The malignant cells gradually replace, and inhibit the growth and maturation of, normal erythroid, myeloid, and megakaryocytic precursors. Included among the names for this condition are acute myelogenous leukemia, acute myelocytic leukemia, acute myeloid leukemia, acute myeloblastic leukemia, acute granulocytic...
BACKGROUND The hypocellular variant of acute myeloid leukemia accounts for less than 10% of all cases of adult acute myeloid leukemia. It is defined by having less than 20 percent of cellular bone marrow in a biopsy at presentation. It is unclear in the literature whether the outcome of hypocellular acute myeloid leukemia differs from that of non-hypocellular acute myeloid leukemia. DESIGN AN...
investigation of leptin, leukemia inhibitory factor (lif), and il-6 serum levels in myeloid leukemia
background: leptin has been implicated in the differentiation and proliferation of hematopoietic cells. leukemia inhibitory factor (lif) may play an important role, along with interleukin-6 (il-6) and granulocyte colony stimulating factor (g- csf), in the regulation of early hematopoietic stem cells. the aim of the study was to evaluate serum level of leptin, lif, and il-6 in myeloid leukemia p...
Tyrosine kinase inhibitors (TKIs) are the mainstay of current management chronic myeloid leukemia (CML) [1]. With introduction imatinib, many CML patients in phase (CML-CP) we...
Acute myeloid leukemia carrying NPM1 mutations and cytoplasmic nucleophosmin (NPMc(+) acute myeloid leukemia) represents one-third of adult AML (50-60% of all acute myeloid leukemia with normal karyotype) and shows distinct biological, pathological and clinical features. We confirm in 2562 patients with acute myeloid leukemia our previous observation that NPM1 mutations and cytoplasmic nucleoph...
This summary is intended to update the Brazilian Society of Bone Marrow Transplantation and Cellular Therapy (SBTMO) 2020/1 consensus on HSCT for Acute Myeloid leukemia (AML).
MicroRNAs are small, non-coding sequences that regulate gene expression by inducing degradation or translational inhibition of target mRNAs. These molecules control many intracellular physiological and pathological processes.Abnormal expression of these moleculs has been described in different cancers including hematopoietic cancers. According to the type of cancer and the stage, miRNA’s expres...
Background and Objective: Chronic myeloid leukemia (CML) is a malignant clonal disorder of hematopoietic stem cells which results in increase of myeloid and erythroid cells and platelets in the peripheral blood and hyperplasia in bone marrow. This research evaluated the cytotoxic effect of aqueous, methanolic and ethanolic extracts of M. spicata leaves on K562 cell line as a model of chronic my...
The recent identification of DNMT3A mutations in de novo acute myeloid leukemia prompted us to determine their frequency, patterns and clinical impact in a cohort of 98 patients with either therapy-related or secondary acute myeloid leukemia developing from an antecedent hematologic disorder. We identified 24 somatic mutations in 23 patients with a significantly higher frequency in secondary ac...
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