نتایج جستجو برای: myeloablative conditioning

تعداد نتایج: 48131  

Journal: :Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis 2011
Sophie Servais Frédéric Baron Yves Beguin

Allogeneic hematopoietic stem cell transplantation (HSCT) following myeloablative (conventional) conditioning regimen is associated with a high incidence of transplant-related morbidity and mortality, limiting its use to younger patients without medical co-morbidities. Over the past few years, it has become more evident that the alloreactivity of transplanted donor immunocompetent cells against...

2013
Sung-Nam Lim Je-Hwan Lee Jung-Hee Lee Dae-Young Kim Sung Doo Kim Young-A Kang Young-Shin Lee Kyoo-Hyung Lee

BACKGROUND In adults, the 2 main types of myelodysplastic/myeloproliferative neoplasms (MDS/MPN) are chronic myelomonocytic leukemia (CMML) and atypical chronic myeloid leukemia (aCML). Both are associated with a poor prognosis. Allogeneic hematopoietic cell transplantation (HCT) is the only known curative treatment modality for these diseases, but data on outcomes following such treatment are ...

2014
Koichi Hirabayashi Yozo Nakazawa Kazuo Sakashita Takashi Kurata Shoji Saito Kentaro Yoshikawa Miyuki Tanaka Ryu Yanagisawa Kenichi Koike

Conventional myeloablative conditioning (MAC) regimens often cause severe regimen-related toxicity (RRT). Furthermore, many patients suffer from poor quality of life in accordance with the increase in long-term survivors. We therefore devised a reduced-toxicity myeloablative conditioning (RTMAC) regimen consisting of 8-Gy total body irradiation (TBI), fludarabine (FLU) and cyclophosphamide (CY)...

Journal: :Alimentary pharmacology & therapeutics 2015
E Montassier T Gastinne P Vangay G A Al-Ghalith S Bruley des Varannes S Massart P Moreau G Potel M F de La Cochetière E Batard D Knights

BACKGROUND Chemotherapy is commonly used as myeloablative conditioning treatment to prepare patients for haematopoietic stem cell transplantation (HSCT). Chemotherapy leads to several side effects, with gastrointestinal (GI) mucositis being one of the most frequent. Current models of GI mucositis pathophysiology are generally silent on the role of the intestinal microbiome. AIM To identify fu...

2013
Chotima Böttcher Francisco Fernández-Klett Nadine Gladow Simone Rolfes Josef Priller

Bone marrow-derived cells (BMDCs) are able to colonize the central nervous system (CNS) at sites of damage. This ability makes BMDCs an ideal cellular vehicle for transferring therapeutic genes/molecules to the CNS. However, conditioning is required for bone marrow-derived myeloid cells to engraft in the brain, which so far has been achieved by total body irradiation (TBI) and by chemotherapy (...

2009
Masahiro Imamura Junji Tanaka

Nonmyeloablative stem cell transplantation (NST) is increasingly used with beneficial effects because it can be applied to older patients with hematological malignancies and those with various complications who are not suitable for conventional myeloablative stem cell transplantation (CST). Various conditioning regimens differ in their myeloablative and immunosuppressive intensity. Regardless o...

2011
Warren L. Denning Jun Xu Siqi Guo Christopher A. Klug Zdenek Hel

Harnessing the ability of cytotoxic T lymphocytes (CTLs) to recognize and eradicate tumor or pathogen-infected cells is a critical goal of modern immune-based therapies. Although multiple immunization strategies efficiently induce high levels of antigen-specific CTLs, the initial increase is typically followed by a rapid contraction phase resulting in a sharp decline in the frequency of functio...

Journal: :Hematology. American Society of Hematology. Education Program 2006
Bart L Scott Brenda M Sandmaier

Reduced-intensity conditioning (RIC) regimens were initially introduced to provide allogeneic stem cell transplantation (HCT), a potentially curative procedure for myeloid malignancies, for patients who were not considered eligible for conventional myeloablative HCT either because of advanced age or excessive comorbidities. A variety of RIC regimens have been studied. The exact definition of RI...

Journal: :Blood 2004
William J Hogan Michael Maris Barry Storer Brenda M Sandmaier David G Maloney H Gary Schoch Ann E Woolfrey Howard M Shulman Rainer Storb George B McDonald

Liver injury is a frequent, serious complication of allogeneic hematopoietic cell transplantation (HCT) following myeloablative preparative regimens. We sought to determine the frequency and severity of hepatic injury after nonmyeloablative conditioning and its relationship to outcomes. One hundred ninety-three consecutive patients who received 2 Gy total body irradiation with or without fludar...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید