Protein kinase Cδ (PKCδ), an isoform of PKC, has been shown to act as a critical mediator of tumor progression and apoptosis; however, its role in musculoskeletal tumors is still unknown. In the current study, we examined the expression of PKCδ in human musculoskeletal tumor tissue samples, and investigated the effects of siRNA downregulation of PKCδ on human malignant fibrous histiocytoma (MFH...

in this session, we will discuss 7 cases in pediatric musculoskeletal field. these cases will include different aspects of bone and msk disorders in pediatrics such as bone tumors (benign and malignant), bone involvement in metabolic and hematologic disorders, infectious diseases and soft tissue vascular lesions. during this session, we will ask some volunteered radiology residents to explain t...

background & objectives: in the 6-billion-population world 2000, approximately 10 million cancers were diagnosed, among which there were an estimated 6.2 million cancer deaths. whereas the universality of cancer incidence and mortality is established, the burden of cancer by type or organ site is distributed unequally between developing and industrialized nations. we want to collect some inform...

BACKGROUND We previously reported that caffeine-potentiated chemotherapy induced significantly good response in patients with musculoskeletal sarcomas. In that series, patients with metastatic carcinoma or lymphoma were treated with caffeine-potentiated chemotherapy. PATIENTS AND METHODS Five patients with metastatic carcinoma or lymphoma were treated with caffeine-potentiated chemotherapy. ...

585 Biopsy refers to tissue sampling for histological examination, diagnosis, classification, and grading of a tumor. The goal of biopsy is to obtain a diagnostic tissue sample without complications, tumor spread, and compromise of future treatments.1,2 As a rule, all lesions should be biopsied as if they were malignant,2,3 and all soft tissue masses 3 cm or larger in diameter or growing lesion...