Patients with occupational hand dystonias have task-specific involuntary co-contraction and overflow of activity to inappropriate muscles. This interferes with highly skilled movements such as handwriting (writer's cramp) or playing a musical instrument (musician's cramp). Transcranial stimulation methods that probe mechanisms of synaptic plasticity in the motor cortex show an abnormal modifiab...

Key words: acute renal failure; Becker muscular dys-legs. These cramps were never associated with dark trophy; mitochondrial creatine kinase; myoglobinuria coloured urine. The patient's mother indicated that pregnancy and delivery were both normal. The family history was negative for neuromuscular diseases. On examination, the patient had no swelling of

Pendahuluan: Chronic Kidney Disease (CKD) yang terjadi > 3 bulan dan ditunjukan oleh nilai laju filtrasi glomerulus (GFR) < 15 ml/menit/1,73m2 pada tahap stadium akhir (End Stage Renal (ESRD)) diperlukan terapi pengganti ginjal, yaitu salah satunya hemodialisis. Salah satu permasalahan sering dikeluhkan pasien hemodialisis rutin adalah muscle cramp, biasanya dirasakan jam sebelum selesai ...

The excitability of inhibitory circuits in patients with writer's cramp is reduced at multiple levels within the sensorimotor system, including the primary motor hand area (M1). Although this may play a major role in the pathophysiology of writer's cramp, it is still unclear what factors may cause the imbalance between inhibition and excitation to arise. One possibility is that homeostatic mech...

Antimicrobial peptides (AMPs), such as β-defensins and cathelicidins, are essential components of innate and adaptive immunity owing to their extensive multifunctional activities. However, their role in fungal infection in vivo remains elusive. In this study, we investigated the protective effect of murine β-defensin 3 (mBD3), mBD4, and the cathelicidin cathelin-related antimicrobial peptide (C...

The effects of dantrolene sodium and diazepam were compared in a double crossover study of 42 patients with spasticity due to stable multiple sclerosis. Both drugs reduced the findings of spasticity, clonus, and hyperreflexia, and the complaints of muscle stiffness and cramping. Each drug had different side effects which suggest indications and contraindications for its use in spastic patients.

The case is described of a 51-year-old man with a 21 year history of severe, long-lasting and widespread muscle cramps. Physical examination revealed muscle hypertrophy and fasciculation; electromyography showed spontaneously active motor units which disappeared during sleep. Cramps could be aborted by ice or mechanical vibration but the most effective management was achieved using transcutaeno...