Associations between latitude and the prevalence of multiple sclerosis are well recognized,1–3 although the association is not seen in some geographical regions.4 The 2006 New Zealand National Multiple Sclerosis Prevalence Study (NZMSPS)5 reported a three-fold increase in multiple sclerosis prevalence with increasing latitude from northern (37.9°S) to southern (45.8°S) regions of New Zealand. I...

Spasticity is most commonly defined as an inappropriate, velocity dependent, increase in muscle tonic stretch reflexes, due to the amplified reactivity of motor segments to sensory input. It forms one component of the upper motor neuron syndrome and often leads to muscle stiffness and disability. Spasticity can, therefore, be measured through electrophysiological, biomechanical and clinical eva...

BACKGROUND There is a poor correlation between multiple sclerosis disease activity, as measured by magnetic resonance imaging, and clinical disability. OBJECTIVE To establish oculographic criteria for the diagnosis and severity of internuclear ophthalmoparesis (INO), so that future studies can link the severity of ocular dysconjugacy with neuroradiological abnormalities within the dorsomedial...

Abstract Background The role of adipokines such as leptin and adiponectin in regulating the immunity has been documented, however data concerning their consequence on multiple sclerosis (MS) Egyptian patients are deficient. aim this study is to demonstrate serum levels MS assess association with disease disability severity. A case–control including 60 subjects (30 30 age, sex body mass index-ma...

Background & Aims: Substance abuse may have different effects on multiple sclerosis. Till now, studies on substance abuse and its correlation with psychopathology, type and severity of multiple sclerosis are limited. We conducted this study to evaluate the psychopathology of patients with multiple sclerosis with and without substance abuse. Methods: In this case-control, cross-sectional study p...

BACKGROUND Multiple sclerosis is a polysymptomatic disease. Little is known about relative contributions of the different multiple sclerosis symptoms to self-perception of health. OBJECTIVES To investigate the relationship between symptom severity in 11 domains affected by multiple sclerosis and self-rated health. METHODS Multiple sclerosis patients in two multiple sclerosis centers assesse...

A multi-secret sharing scheme (MSS) allows a dealer to share multiple secrets among a set of participants. in such a way a multi-secret sharing scheme (MSS) allows a dealer to share multiple secrets among a set of participants, such that any authorized subset of participants can reconstruct the secrets. Up to now, existing MSSs either require too long shares for participants to be perfect secur...

B cells are involved in driving relapsing-remitting multiple sclerosis (RRMS), as demonstrated by the positive effect of therapeutic B-cell depletion. Aside from producing antibodies, B cells are efficient antigen-presenting and cytokine-secreting cells. Diverse polyclonal stimuli have been used to study cytokine production by B cells, but here we used the physiologically relevant self-antigen ...

Background: Since in multiple sclerosis (MS), changes in speech and voice quality often precede other signs and symptoms; early diagnosis of these changes is necessary. In this study, an acoustic examination of phonation subsystem was performed. Due to the progressive nature of multiple sclerosis, the aim of this study was to examine the correlation between acoustic parameters ...