thirty seven randomly selected patients suffering from multiple s c l e r os i s (ms) (17 males and 20 females)and 30 healthy control subjects were studied for the lymphocyte subpopulations and ce l l -medi a t e d immunity.we obs e r ved a decrease of the total t-cells and an increase of a ctive t-lymphocytes and b ce l l s , in ms p at i ent s as compared t o normal controls. the inability of...

Chimeric antigen receptors redirect T cells to surface antigens. Discovery and validation of appropriate target antigens expands the possible indications for chimeric-antigen receptor (CAR) T cells. CS1 is expressed at high levels by multiple myeloma cells, but also to some extent on other lymphocytes. CS1 may be a viable target for CAR T cells in multiple myeloma.

In a vaccine trial setting, intracellular cytokine staining assays measure whether individuals respond to a vaccine. They do so by measuring how antigen-specific T–cells respond to antigen stimulation. Antigen-specific T–cells that respond to antigen express one or multiple cytokines (i.e., IFNg, IL2, TNFa, IL4). The strength of response is measured as the fraction of antigen-specific T-cells e...