Patient noncompliance to current tuberculosis (TB) therapy owing to multidrug administration daily leads to treatment failure and emergence of multidrug resistant and extensively drug resistant TB. To avoid the daily dosing, application of nanotechnology is the only viable solution by virtue of sustained release of drugs. Other potential advantages of the system include the possibility of selec...

Multidrug resistance is a phenomenon that cancer cells develop a cross-resistant phenotype against several unrelated drugs, and permeability glycoprotein derived from the overexpression of multidrug resistance gene 1 has been taken as the most significant cause of multidrug resistance. In the present study, ginsenoside Rh2 was used to reverse permeability glycoprotein-mediated multidrug resista...

Background: Typhoid fever is one of the most common infectious diseases in developing countries including Nigeria. Globally, typhoid an important cause morbidity and mortality many regions world. People at risk for serious complications due to Salmonella infections include older adults, pregnant women, infants, children, people who have compromised immune systems.
 Design Duration: The stu...

amikacin has been shown to irreversibly suppresscochlear activity.the aim of this study is to assess the incidence of amikacinototoxicity in multidrug-resistant tuberculosis patients and riskfactors associated withthis ototoxicity.in this cross-sectional study, 41 patientswith multidrug-resistant tuberculosis (mdr-tb) were included.all patients received fixed dose of intravenous amikacin(500 mg...

introduction: tuberculosis (tb) remains a deadly infectious disease despite all the efforts to reduce its incidence. spread of multidrug resistant tb has seriously undermined the efforts to control the disease globally. in this study protein expression profile of mdr and sensitive isolates of mtb were analyzed and compared in order to identify proteins, which could be used in prevention, diagno...

background and objectives: the prevalence of multidrug resistant pseudomonas aeruginosa is the main reason of new drugs resurgence such as colistin. the main objectives of this study were to determine the antibiotic resistance pattern and the rate of colistin resistance along with its correlation with overexpression of mexab-oprm and mexxy-oprm efflux pumps among p. aeruginosa isolates. materia...

Kon K. 2015. Prevalence of multidrug resistant bacteria in General Surgery Hospital, Ukraine. Nusantara Bioscience 7: 102106. Rising antibiotic resistance is a serious concern worldwide and during prescribing antibiotic treatment it is important to know general and regional tendencies in spread of multidrug resistant strains. The aim of the present study was to evaluate regional specificity of ...