background: bone marrow-derived mesenchymal stem cells (bmmscs) transplantation has been considered as a promising milestone in liver fibrosis treatment. however, low amounts of homing are a major obstacle. we aimed to investigate the role of melatonin pretreatment in bmmsc homing into experimental liver fibrosis. methods: bmmscs were obtained, grown, propagated and preconditioned with 5 µm mel...

Advances in cancer immunotherapy have offered new hope for patients with metastatic disease. This unfolding success story has been exemplified by a growing arsenal of novel immunotherapeutics, including blocking antibodies targeting immune checkpoint pathways, cancer vaccines, and adoptive cell therapy (ACT). Nonetheless, clinical benefit remains highly variable and patient-specific, in part, b...

For efficient Internet Connectivity in MANETs, multiple gateways and potentially multi-homing and hand-over need to be supported. We compare how default routes and tunneling to gateways support this. We find that tunneling is more efficient and flexible compared to default routes. In fact, we show that default routes will not operate correctly in some situations, particularly when there are mul...

Secure Shell (SSH) is a multi-channel security protocol running over the Transmission Control Protocol (TCP), which offers channels for several services over a secured connection, such as remote shells and connection forwarding. In this paper we introduce a method for using SSH over the Stream Control Transmission Protocol (SCTP), a transport protocol supporting multi-homing and multi-streaming...

We contribute to the analysis of mergers in two-sided markets, which a platform provides its service for free on one side but obtains all revenues from other. A structural model allowing multi-homing advertisers is developed assess decision French competition authority, approves merger broadcasting services TV channels prohibits their advertising sales through behavioral remedy. show that ignor...

stem/progenitor cell based therapeutic approach in our daily routine clinical practice, has been elusive dream in medical sciences and improvement of stem cell homing as one of major challenges in cell therapy programs, has been considered a promising milestone. it has been proved that stem/progenitor cells exhibit a homing response to injured tissues/organs, mediated by interactions of chemoki...