نتایج جستجو برای: mucosal vaccine delivery
تعداد نتایج: 344745 فیلتر نتایج به سال:
We tested the concept of combining DNA with protein to improve anti-HIV Env systemic and mucosal humoral immune responses. Rhesus macaques were vaccinated with DNA, DNA&protein co-immunization or DNA prime followed by protein boost, and the magnitude and mucosal dissemination of the antibody responses were monitored in both plasma and mucosal secretions. We achieved induction of robust humoral ...
Currently, mucosal vaccine administration has stood out as an easier and non-invasive application method. It can also be used to induce local systemic immune responses. In the COVID-19 pandemic context, nasal oral vaccines have been developed based on different technological platforms. This review addressed relevant aspects of administration, with emphasis vaccinations, in addition importance u...
BACKGROUND Newcastle disease (ND) is a highly contagious viral disease of poultry caused by pathogenic strains of the Newcastle disease virus (NDV). Live NDV vaccines are administered by drinking water, eyedrops or coarse aerosol spray. To further enhance mucosal immune responses, chitosan nanoparticles were developed for the mucosal delivery of a live NDV vaccine. METHODOLOGY/PRINCIPAL FINDI...
Mucosal vaccines are thought to confer superior protection against mucosal infectious diseases. In addition, mucosal routes of vaccine delivery preferentially induce the generation of T helper 17 (Th17) cells, which produce the cytokine IL-17. Th17 cells are critical in mediating vaccine-induced immunity against several mucosal infectious diseases. However, IL-17 is also a potent proinflammator...
Diarrhea is one of the top disease killers in newborns and young infants of the developing world, yet the research funding for vaccine development of enteric diseases falls far behind the investment that has been made in preventing diseases with lower burden to the world’s population. Advances in this field have been delayed not only due to poor funding, but also due to knowledge gaps in our un...
There are several benefits of oral immunization including the ability to elicit mucosal immune responses that may protect against pathogens that invade through a mucosal surface. Our understanding of human immune biology is hampered by the difficulty in isolating mucosal cells from humans, and the fact that animal models may or may not completely mirror human intestinal immunobiology. In this h...
Administering vaccines directly to mucosal surfaces can induce both serum and mucosal immune responses. Mucosal responses may prevent establishment of initial infection at the port of entry and subsequent dissemination to other sites. The sublingual route is attractive for mucosal vaccination, but both a safe, potent adjuvant and a novel formulation are needed to achieve an adequate immune resp...
BACKGROUND The respiratory illnesses caused by influenza virus can be dramatically reduced by vaccination. The current trivalent inactivated influenza vaccine is effective in eliciting systemic virus-specific antibodies sufficient to control viral replication. However, influenza protection generated after parenteral immunization could be improved by the induction of mucosal immune responses. ...
lmmunocontraceptive Vaccines for Control of Fertility in the European Red Fox (<i>Vulpes vulpes</i>)
This paper describes the strategies being requires the identification of gamete antigens that cause employed in the development of an immunocontraceptive immunological infertility, a detailed understanding of the vaccine using sperm antigens, to control fox populations in reproductive immunology of foxes, and the selection of the Australia. It is proposed that such a vaccine will be most effect...
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