نتایج جستجو برای: mtx sensor

تعداد نتایج: 192151  

Ebrahim Azizi, Elmira Barzegar, Mohammad Hossein Ghahremani Seyed Nasser Ostad, Shamileh Fouladdel, Shekoufeh Atashpour, Tahereh Komeili-Movahhed Zahra Madjd,

Objective(s):Multidrug resistance (MDR) of cancer cells is a major obstacle to successful chemotherapy. Overexpression of breast cancer resistance protein (BCRP) is one of the major causes of MDR. In addition, it has been shown that PI3K/Akt signaling pathway involves in drug resistance. Therefore, we evaluated the effects of novel approaches including siRNA directed against BCRP and targeted t...

Uveitis is a major cause of vision loss. Methotrexate (MTX) has been widely used in uveitis due to its relatively safe profile. The purpose of this study was to evaluate the effects of two different dosages of MTX via intra-vitreal administration for treatment of endotoxin induced uveitis (EIU) in an experimental model. Thirty-five healthy rabbits were randomly divided into four groups and all ...

Ahmadi A, Gheibi S Sadrkhanlou RA Shahrooz R Valipour S Zarei L,

Background: Because of stress oxidative side effect of MTX on reproductive system, current study was aimed to evaluate protective effects of cornus mas fruit extract (CMFE) in mice treated with methotrexate (MTX). Materials and Methods: 48 young mature male mice were classified in 4 groups. Control group received only normal saline orally (0.2 ml/day), and the second group was administered MTX ...

2011
Azade Taheri Rassoul Dinarvand Faranak Salman Nouri Mohammad Reza Khorramizadeh Atefeh Taheri Borougeni Pooria Mansoori Fatemeh Atyabi

Biotin molecules could be used as suitable targeting moieties in targeted drug delivery systems against tumors. To develop a biotin targeted drug delivery system, we employed human serum albumin (HSA) as a carrier. Methotrexate (MTX) molecules were conjugated to HSA. MTX-HSA nanoparticles (MTX-HSA NPs) were prepared from these conjugates by cross-linking the HSA molecules. Biotin molecules were...

Journal: :The Journal of biological chemistry 1991
D E McCloskey J J McGuire C A Russell B G Rowan J R Bertino G Pizzorno E Mini

Determinants of methotrexate (MTX) resistance in cell lines resistant to short, but not continuous, MTX exposure were investigated since such lines may have relevance to clinical resistance. CCRF-CEM R30dm (R30dm), cloned from CCRF-CEM R30/6 (a MTX-resistant subline of the CCRF-CEM human leukemia cell line), had growth characteristics similar to CCRF-CEM. R30dm was resistant to a 24-h exposure ...

2005
Garan Gustafsson Jon Kristinsson Anders Glomstein Toivo Salmi

Purpose: During maintenance chemotherapy for childhood acute lymphoblastic leukemia (ALL), the cytotoxic metabolites of methotrexate (MTX polyglutamates) and mercaptopurine (6MP) (thioguanine nucleotides [6TGN]) accumulate intracellularly, including in erythrocytes (E-MTX and E-6TGN) with large interindividual variations. In the present Nordic Society for Pediatric Hematology and Oncology (NOPH...

Objective: The long-term sequelae of methotrexate (MTX) remain the major cause of concern for both patients and therapists. Therefore, new approaches to decrease MTX side effects are needed. The study was carried out to evaluate the effects of Iris songarica Schrenk (IS) rhizome extract against MTX-induced hepatic and renal injuries in rats. Materials and...

2017
P Emery C O Bingham G R Burmester V P Bykerk D E Furst X Mariette D van der Heijde R van Vollenhoven C Arendt I Mountian O Purcaru D Tatla B VanLunen M E Weinblatt

OBJECTIVES To assess the efficacy and safety of certolizumab pegol (CZP)+dose-optimised methotrexate (MTX) versus placebo (PBO)+dose-optimised MTX in inducing and sustaining clinical remission in DMARD-naïve patients with moderate-to-severe, active, progressive rheumatoid arthritis (RA), with poor prognostic factors over 52 weeks. METHODS DMARD-naïve patients with ≤1 year of active RA were ra...

Journal: :Arthritis and rheumatism 2004
E William St Clair Désirée M F M van der Heijde Josef S Smolen Ravinder N Maini Joan M Bathon Paul Emery Edward Keystone Michael Schiff Joachim R Kalden Ben Wang Kimberly Dewoody Roberta Weiss Daniel Baker

OBJECTIVE To compare the benefits of initiating treatment with methotrexate (MTX) and infliximab (anti-tumor necrosis factor alpha [anti-TNFalpha] monoclonal antibody) with those of MTX treatment alone in patients with rheumatoid arthritis (RA) of < or =3 years' duration. METHODS RA patients were eligible if they had active disease and no prior treatment with MTX or a TNFalpha inhibitor. One ...

2008
HM Albers JAM Wessels RJH van der Straaten DMC Brinkman LWA Suijlekom-Smit SSM Kamphuis HJ Girschick C Wouters MW Schilham S le Cessie TWJ Huizinga R ten Cate HJ Guchelaar

OBJECTIVE Methotrexate (MTX) is the most commonly used disease-modifying antirheumatic drug in juvenile idiopathic arthritis (JIA). Currently, individual response to MTX cannot be reliably predicted. Identification of clinical and genetic factors that influence the response to MTX could be helpful in realizing the optimal treatment for individual patients. METHODS A cohort of 128 JIA patients...

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