Introduction Recently it was shown that top-down microfabrication could be used to engineer precisely shaped magnetic microparticles that function as MRI contrast agents with tunable NMR spectral signatures [1]. The agents operated similarly to CEST / PARACEST agents [2,3], except with continuously tunable frequency shifts determined by control of the particle geometry, and with a magnetization...

Manganese zinc ferrite nanoparticles (MZF NPs) were synthesized by using a direct, efficient and environmental friendly hydrothermal method. To improve the colloidal stability of MZF NPs for biomedical applications, NPs were coated with chitosan by ionic gelation technique using sodium tripolyphosphate (TPP) as crosslinker. The synthesized NPs were characterized by X ray diffraction (XRD) analy...

Purpose The utility of (super)paramagnetic agents to enhance contrast in MRI has been for some time demonstrated in human studies. The contrast provided by these agents arises from their ability to achieve reductions in T1 and T2*. Another approach to designing contrast agents is to consider the use of ultrasound (US). We have developed a method involving the application of US in MRI in the pre...

O G Inorganic Nanoparticles for MRI Contrast Agents R E S By Hyon Bin Na, In Chan Song, and Taeghwan Hyeon* S R E P O R T Various inorganic nanoparticles have been used as magnetic resonance imaging (MRI) contrast agents due to their unique properties, such as large surface area and efficient contrasting effect. Since the first use of superparamagnetic iron oxide (SPIO) as a liver contrast agen...

The advent of the molecular imaging era has offered to pharmacologists very powerful tools for drug discovery and development, in vivo evaluation of pharmacokinetic properties, andmonitoring drug efficacy (Hargreaves, 2008; Nairne et al., 2015). In fact, molecular imaging technologies provide minimally invasive procedures to visualize, characterize, and quantify biological processes occurring a...