Cathepsin K, a papain-like cysteine protease, is highly expressed in osteoclasts and plays a critical role in bone resorption. Dysfunction of the enzyme leads to various skeletal abnormalities. The recent knowledge that the collagenolytic activity of cathepsin K depends on interactions with bone and cartilage-resident glycosaminoglycans (GAGs) may shed some light on diseases such as mucopolysac...

There is growing evidence that personality traits are affected by many genes, all of which have very small effects. As an alternative to the largely unsuccessful search for individual polymorphisms associated with personality traits, the authors identified large sets of potentially related single nucleotide polymorphisms (SNPs) and summed them to form molecular personality scales (MPSs) with fr...

This paper proposes the application of a hierarchical fuzzy system (HFS) based on multi-input power system stabilizer (MPSS) and also Static Var Compensator (SVC) in multi-machine environment.The number of rules grows exponentially with the number of variables in a conventional fuzzy logic system. The proposed HFS method is developed to solve this problem. To reduce the number of rules the HFS ...

In this paper the geometric entanglement (GE) of systems in one spatial dimension (1D) and in the thermodynamic limit is analyzed focusing on two aspects. First, we reexamine the calculation of the GE for translation-invariant matrix product states (MPSs) in the limit of infinite system size. We obtain a lower bound to the GE which collapses to an equality under certain sufficient conditions th...

The aim of this study was to examine the reliability and validity of a Chinese-version stress instrument among emergency nurses. The study sample comprised of 113 nurses whose age ranged from 21 to 47 years old. The Chinese version of Medical Personnel Stress Survey (MPSS-R) was answered in 1996 through self-administered questionnaires. The instrument demonstrated excellent convergent and discr...

in this paper, it is assumed that the “decision making units“( ) are consist of positive and negative input and output. firstly, the optimistic and pessimistic models have been suggested by using negative data and then units with most productive scale size are measured in optimistic and pessimistic models. these productive values are compared with double frontiers and hurwicz’s criterion to obt...

Economics depends on the economic scale of planning. Economists study the characteristics of the production function, while community operating management focuses on demand realization, so that loss of sales or inventory prevents cost reductions and maximizes profits. However, companies with a lack of capacity need to achieve economies of scale and demand to realize them simultaneously, especia...

Our recent article opened a valuable discussion on the safety of miniaturized perfusion systems (MPSs) with respect to the risk of gaseous microemboli (GME) [1, 2]. We would like to comment on this. Although the clinical advantages of MPSs are well known, it is still important to focus on avoiding possible side effects in order to increase patient safety [3]. In our study, we observed excessive...

In recent years, probabilistic model building genetic programming (PMBGP) for program optimization has attracted considerable interest. PMBGPs generally use probabilistic logic sampling (PLS) to generate new individuals. However, the generation of the most probable solutions (MPSs), i.e., solutions with the highest probability, is not guaranteed. In the present paper, we introduce loopy belief ...