BACKGROUND A large number of hand, foot and mouth disease (HFMD) outbreaks was reported during 2008 in China. However, little is known about the effects of meteorological conditions on different temporal and spatial scales on HFMD incidence in children. The aim of this study was to explore the relationship between meteorological data on various temporal and spatial scales and HFMD incidence amo...

An improved temperature-shift selection and screening method is described for the isolation of temperature-sensitive mutants of foot and mouth disease virus.

Antigenic variation of type Asia 1 foot and mouth disease (FMD) virus in Thailand was examined using a total of 50 field viruses isolated between 1986 and 1992. A two-dimensional serum neutralisation test was used to calculate r values for comparison of these isolates with a reference vaccine strain, Asia 1 Bangkok 1960 (BKK/60). Viruses were also compared to two field isolates, Asia 1 36-2/88 ...

Comparison of nucleotide sequences of the partial 1D region of foot-and-mouth disease type C viruses of Indian origin with those of European, South American, and Southeast Asian viruses revealed that the Indian viruses form a distinct genotype. The vaccine strain C IND/51/79 belongs to this genotype and may be a prototype strain of this genotype.

OBJECTIVE To estimate potential spread of foot-and-mouth disease (FMD) if introduced from wild pigs in California and to evaluate efficacies of various control strategies. SAMPLE POPULATION Data for California livestock and from hunter surveys on wild pigs in California. PROCEDURES A spatial, stochastic simulation model was used to simulate FMD epidemics that might occur if a dairy or beef ...

1970年,北 海 道 にHand,foot and mouth disease の 大 き な流 行 の あつ た 際 に,Coxsackie A 16と こ の ウ イル ス 以外 にCoxsackie Aウ イ ル ス が分 離 され た. これ らの うち,帯 広,旭 川,札 幌 の3地 区 の 患者153 名 か ら,サ ル 腎 初 代 培 養 細 胞 に よつ てCoxsackie A 16 が79株(51.6%),未 同定 の ウイ ル ス が25株(16.3%) が分 離 され た. 一 方 ,同 一 被 検 体 を 哺 乳 マ ウス接 種 に よつ て,Coxsackie A 16が61株(39.9%)分 離 され た ほ か に,Coxsackie A4が17株(11.1%),A5が27株(17.6%),A6 が63株(41.2%),A10が9株(5.9%)が 分...

Control and prevention of foot and mouth disease (FMD) by vaccination remains unsatisfactory in endemic countries. Indeed, consistent and new FMD epidemics in previously disease-free countries have precipitated the need for a worldwide control strategy. Outbreaks in vaccinated animals require that a new and safe vaccine be developed against foot and mouth virus (FMDV). FMDV can be eradicated wo...

INTRODUCTION Hand, foot and mouth disease (HFMD) caused by EV71 infection has become one of the major public health issues in China, which deeply affects children's health. The prevention and control of EV71 is a challenge currently because there is no safe and effective vaccine or antiviral medications available. MATERIAL AND METHODS A case control study was conducted in a designated hospita...

Complement-fixation patterns were established for four subtypes of foot-and-mouth disease virus by block assays against homologous and heterologous antiserum. Inhibition of fixation by excess antigen was observed in most homologous systems but rarely in the heterologous systems. The heterologous antibody titers were, in all instances, considerably lower than those for the homologous systems. Al...

In order to tackle both regional and global foot-and-mouth disease virus (FMDV) epdimics, we hereby develop a rapid microfluidic thermal lens microscopic method to screen swine type O FMDV with good efficiency. The scheme has great merits in terms of field portability, sample volume, assay time, analytical sensitivity, and test reproducibility.