background while tocolytic therapy can halt the process of delivery, some patients return before the 37th week of pregnancy with recurrence of preterm labor signs. objectives this study was designed to evaluate the efficacy of progesterone in the prolonging of gestation and reduction of neonatal complications. material and methods in a clinical trial in 2010, 110 singleton pregnant women admitt...

Notch signaling pathways exert effects throughout pregnancy and are activated in response to TLR ligands. To investigate the role of Notch signaling in preterm labor, Notch receptors (Notch1-4), its ligand Delta-like protein-1, transcriptional repressor hairy and enhancer of split-1, and Notch deregulator Numb were assessed. Preterm labor was initiated on gestation d 14.5 by 1 of 2 methods: 1) ...

Objective Threatened miscarriage is a common complication in pregnancy that leads to adverse pregnancy outcomes such as preterm labor. This study aimed to compare the vaginal progesterone (Cyclogest) versus 17-alpha-hydroxyprogesterone caproate (Proluton) on preventing preterm labor in pregnant women with threatened abortion at less than 34 weeks’ gestational age. MaterialsAndMethods This balan...

This cross-sectional study assessed the association between smoking and child and adolescent labor among 3,269 individuals 10 to 17 years of age in Pelotas, Rio Grande do Sul State, in southern Brazil (excluding higher income census tracts) in 1998. Adjusted hierarchical analysis was performed using Poisson regression. Prevalence of child labor was 13.8%. Current smoking prevalence was 6.3% in ...

1.1 General It is agreed by all physicians that preterm labor is comprised of regular uterine contractions, usually <5 minutes apart, that results in cervical change occurring before the 37th week of pregnancy. (Elliott, 2011) Often times, preterm labor can be successfully treated with tocolytic drugs, but when such treatment results in early delivery particularly (<32 weeks) it is devastating ...

Preterm labor is defined as the presence of regular uterine contractions with progressive cervical changes before 37 completed weeks of pregnancy. Spontaneous preterm labor accounts for 40% to 50% of all preterm births [1]. An estimated 13 million babies (−10% of all births) are born preterm each year worldwide, and approximately 1 million of all newborn deaths are due to preterm birth [2]. At ...

Presently, there is no effective treatment for preterm labor. The most obvious reason for this anomaly is that there is no objective manner to evaluate the progression of pregnancy through steps leading to labor, either at term or preterm. Several techniques have been adopted to monitor labor, and/or to diagnose labor, but they are either subjective or indirect, and they do not provide an accur...

We thank Drs. Savitz and Werner (1) for their thoughtful comments about isolating the causal impact of early delivery on neonatal health outcomes. In our article (2), we sought to provide an estimate of the “pure outcome” of shortened gestation resulting from the acute event of unintentional injury during pregnancy and to contrast that outcome with that of preterm birth from other (predominantl...