Fungi are an emerging source of peptide antibiotics. With the availability of a large number of model fungal genome sequences, we can expect that more and more fungal defensin-like peptides (fDLPs) will be discovered by sequence similarity search. Here, we report a total of 69 new fDLPs encoded by 63 genes, in which a group of fDLPs derived from dermatophytes are defined as a new family (fDEF8)...

Fluorescent phosphatidic acid and phosphatidylcholine were used to characterize lipid-transport pathways into lipid bodies in an oleaginous fungus, Mortierella ramanniana var. angulispora. Several characteristics of the lipid transport such as temperature dependence and ATP dependence were evaluated. The transport depicted by these fluorescent lipids was consistent with metabolism of radiolabel...

Microsomal membrane preparations from Mortierella alpina catalysed the conversion of sn-glycerol 3-phosphate and [(14)C]oleoyl-CoA to radioactive phosphatidic acid, diacylglycerol and triacylglycerol. Experiments with lysophosphatidic acid and [(14)C]oleoyl-CoA gave a similar pattern of radioactivity in the complex lipids. The specific activity of lysophosphatidate acyltransferase was almost ei...

filamentous fungus, is one of several industrial strains known for the production of arachidonic acid. It is also of particular interest for hydrocarbon biofuel production since it is able to produce up to 50% of its mass in rich, long-chain polyunsaturated fatty acids [PUFA’s]. M. alpina already has mechanisms for accumulating significant concentrations of hydrocarbon compounds, making it a na...

A cymene-derived drug, 3-[4'-(o-ethoxyphenyl)piperazin-1'-yl]-ethyloxy-p-cymene+ ++ (B1178), is not significantly metabolized by fungal microorganisms. On the contrary, one of its metabolites in rat, 3-(piperazin-1'-yl)ethoxy-p-cymene (B1071), is quantitatively converted by Cunninghamella echinulata NRRL 3655 into two hydroxylated products: the corresponding phenol derivative and a benzylic alc...

A substance toxic for mice has been extracted from the washed mycelia of Mortierella wolfii. This toxin could also be demonstrated in culture fluids after spontaneous autolysis of the fungal hyphae. Purification of the toxin was carried out using Sephadex chromatography (G-200, G-50) and resulted in a single band on sodium dodecyl sulfate polyacrylamide gels. Properties of the toxin included he...

This study examined the distribution of culturable fungi and predominant genera in organic layer upper layers mineral soil six broad-leaved tree plantations autumn, after full fall leaves. In total, 1335 fungal isolates were recovered from an two (0–4 cm 5–8 cm) soil. The structure differed three studied layers. was most populated by compared to layer, Penicillium phyllosphere such as Cladospor...