Some studies have shown that Matricaria recutita (M. recutita) have sedative effect on pain, anxiety and morphine withdrawal syndrome (MWS). Since some investigations have indicated the sedative effects of benzodiazepines in MWS, so the inhibitory factor of M. recutita may be related to some of its benzodiazepine-like components. In this study sedative properties of M. recutita in the presence ...

substance abuse is an important health, psychological and social problem in the world. gabapentin is a new antiepileptic drug. it is used in neurological and psychiatric disorders. moreover the effects of gabapentin on increasing the analgesic effect of morphine and its inhibitory effects on dopamine release due to morphine in animal models have been proved. in the present study, the effect of ...

PURPOSE To explore the role of calcium in morphine withdrawal syndrome using various agents affecting calcium levels in cytoplasm. METHODS Mice were rendered dependent on morphine by subcutaneous injection of morphine, and withdrawal was induced 4 hours later by injecting the opioid antagonist, naloxone. Mice were observed for 30 minutes for signs of withdrawal, ie, characteristic jumping, hy...

Various physiological parameters including level of sex steroids undergo alterations following chronic administration of morphine. In this study, the effect of chronic administration of morphine on phasic and tonic pain was studied in morphine-dependent male and female rats in the presence and absence of gonads using formalin test. In addition, for evaluation of differences in dependency, withd...

The present study was conducted to investigate the effect of potassium channel openers and blockers on morphine withdrawal syndrome. Mice were rendered dependent on morphine by subcutaneous injection of morphine; four hours later, withdrawal was induced by using an opioid antagonist, naloxone. Mice were observed for 30 minutes for the withdrawal signs ie, the characteristic jumping, hyperactivi...

Substance abuse is an important hygienic, psychic and social problem in the world. Gabapentin is a new antiepileptic drug that is used in neurological and psychiatric disorders. Moreover, the effects of gabapentin on increasing the analgesic effect of morphine and its inhibitory effect on dopamine release due to morphine in animal models have been proved. In the present study, the effect of gab...

Substance abuse is an important health, psychological and social problem in the world. Gabapentin is a new antiepileptic drug. It is used in neurological and psychiatric disorders. Moreover the effects of gabapentin on increasing the analgesic effect of morphine and its inhibitory effects on dopamine release due to morphine in animal models have been proved. In the present study, the effect of ...

Substance abuse is an important hygienic, psychic and social problem in the world. Gabapentin is a new antiepileptic drug that is used in neurological and psychiatric disorders. Moreover, the effects of gabapentin on increasing the analgesic effect of morphine and its inhibitory effect on dopamine release due to morphine in animal models have been proved. In the present study, the effect of gab...

Chronic use of morphine leads to physical and psychological dependence. The amygdala is known to be involved in the expression of emotion such as anxiety and fear, and several studies have shown that the central nucleus of the amygdala (CeA) is involved in morphine dependence. In the present study, we investigated the role of glutamate receptors within the CeA in the negative affective componen...