نتایج جستجو برای: morphine dependency
تعداد نتایج: 55149 فیلتر نتایج به سال:
introduction: the aim of this study was to assess the effect of ca2+/calmodulin-dependent kinase iiα (camkiiα) inhibitor (kn-93) injection into the locus coeruleus (lc) on the modulation of withdrawal signs. we also sought to study the effect of chronic morphine administration on camkiiα activity in the rat lc. methods: the research was based on behavioral and molecular studies. in the behavior...
background thymus species are well known medicinal plants which the previous studies suggested the involvement of the opioid system in them. objectives this study aimed to investigate the effects of methanolic extract and essential oil of aerial parts of thymus daenensis (td), an endemic aromatic medicinal plant of iran, on morphine withdrawal syndrome in mice. materials and methods experiments...
Opium Dependency and Histopathologic Changes of Brain in Rat R. Malekpour Afshar [1] , R. Seyfaddini [2] , E. Koohpayehzadeh Esfahani [3] , N. Nakhaee [4] , T. Eslammanesh [5] Received: 19/10/09 Sent for Revision: 25/02/10 Received Revised Manuscript: 12/06/10 Accepted: 03/07/10 Background and Objectives: Central nervous system is one of the primary targets of the detrimental effe...
Background The amygdala is one of the nerve centers involved in drug reward. It is suggested that the central nucleus of the amygdala (CeA) is involved in morphine dependency. The CeA gamma-aminobutyric acid-ergic (GABAergic) system is a mediator of morphine rewarding effects. In this research, the effects of stimulation or inhibition of CeA GABA type B (GABAB) receptors on sensitization acquis...
Background and purpose: The exact mechanisms of morphine dependence and withdrawal syndrome remain unclear. Many studies have been performed to find a drug for prevention of withdrawal symptoms. The aim of this study was to evaluate the effect of mefloquine (a gap junction inhibitor) on morphine withdrawal symptoms in male rats. Materials and methods: In an experimental study, adult male Wista...
previous studies have shown that morphine addiction is caused by abnormality in neurotransmission system.serotonin is one of the most important neurotransmiters involved in addiction.the dorsal and median raphe nuclei are the important sites that synthesize and release this neurotransmiters in this study we have injected 5,7 dihyroxytryptamine a serotonergic neurotoxin into the dorsal and medi...
PURPOSE There are several reports about effects of Salvia spp. on CNS. The present experiment is undertaken to study effect of S. limbata, S. hypoleuca and S. macrosiphon on withdrawal syndrome in mice. METHODS Antinociceptive activities of aerial parts of Salvia spp. is investigated using hot plate method. In addition, the effect of its aerial parts on morphine dependence is investigated in ...
Background and Objective: Development of effective ways to impede drug-induced synaptic changes can play a vital role in the treatment and prevention of relapse as a clinical problem. Previous studies suggest that exercise decreases the sensitivity to the rewarding effects of morphine in rats. This study was designed to investigate the effects of regular swimming exercises on naloxone-precipita...
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