Linear morphea in an en coup de sabre pattern is a variant of localized scleroderma that develops on the frontal or frontoparietal scalp. Approximately two-thirds of cases occur before the age of 18. The etiology is unknown, but the disease is thought to be most likely autoimmune in nature. Between 50% and 75% of these patients have been found to have a positive serum antinuclear antibody (ANA)...

Received: Jan 16, 2013 Accepted: Feb 13, 2013 Ann Paediatr Rheum 2013; 2:50-55 DOI: 10.5455/apr. 021320131602 Introduction Morphea or Localized scleroderma (LS) is an idiopathic inflammatory disease of the skin characterized by localized, circumscribed sclerotic patches, or plaques with variable pigmentation. LS has been differentiated from systemic sclerosis based upon the clinical findings of...

INTRODUCTION Morphea (localized scleroderma) is a rare cutaneous disease characterized by skin fibrosis of unknown pathogenesis. Transforming growth factor-β (TGF-β) is a potent profibrotic factor. The role of TGF-β in morphea remains unclear. AIM The goal of this study was to estimate the expression level of TGF-β1 in skin and peripheral blood mononuclear cells as well as the plasma levels o...

INTRODUCTION Morphea (localized scleroderma) is a relatively rare disease characterized by excessive skin fibrosis. Human endogenous retroviruses (HERV) are largely distributed within the human genome with hundreds of thousands of elements. The HERV have been widely studied in autoimmune disorders, yet hardly ever assessed in diseases with a good prognosis such as morphea. AIM In this study w...

We report the case of a 48-year-old woman who developed morphea-like plaques after 1 year of treatment with D-penicillamine at 250 mg daily for a seronegative erosive arthritis of rheumatoid type. The rash began as several red itchy patches on the trunk; these became thickened and shiny over about 3 months. The histological appearance was of increased dermal fibrosis with an inflammatory infilt...

Linear morphea is a distinct form of morphea that occurs as a linear band usually with a single unilateral distribution. The lower extremities are most often involved. This dermatosis appears as a linear induration not necessarily related to the derm induration. We report herein a case of 20-year-old Iranian girl who had a linear sclerotic patch on right lower extremity with clinical and ...

Localized scleroderma, or morphea, is a chronic disease that causes a thickening and induration of the skin. For plaque type morphea, the treatments of choice include super-potent corticosteroids and calcipotriol. For the more generalized forms, as well as the linear forms, UVA is currently the best therapeutic modality. Patients with localized scleroderma are managed by both rheumatologists an...

Sir, We read with great interest the report recently published in the Indian Journal of Dermatology by Balegar et al.,[1] which describes a case of a 27-year-old male who developed radiation-induced progressive generalized morphea after getting radiotherapy (RT) for an intracranial tumor. In this patient, morphea, initially strictly localized on the irradiated zone, appeared some months after t...

The term "scleroderma" traditionally has been uti l ized to describe the cutaneous changes of a heterogeneous group of disorders involving hardening, tightening, and decreased elasticity of the skin.' Two extreme forms have been identified-localized and diffuse. The localized form, specifically morphea, i s characterized by well-circumscribed, sclerotic plaques with an ivory-colored center and ...