The drug thalidomide was contained in the blockbuster Contergan, which has been used as a non- prescription sedative drug and a potent treatment for occurring morning sickness in pregnant women during the 1950s and the early 1960s. This therapeutic use has led to one of the most prominent disasters in the history of drug development due to peripheral neuritis and malformations, e.g. phocomelia,...

A majority of women experience some nausea and/or vomiting during pregnancy. This condition can range from mild nausea to extreme nausea and vomiting, with 1-2% of women suffering from the life-threatening condition hyperemesis gravidarum. Cannabis (Cannabis sativa) may be used therapeutically to mitigate pregnancy-induced nausea and vomiting. This paper presents the results of a survey of 84 f...

As recommended by most recent antiemetic guidelines, the optimal prophylaxis of chemotherapy-induced nausea and vomiting (CINV) requires the combination of 5-HT3 receptor antagonist (RA) with an NK1-RA. Moreover, the major predictors of acute and delayed CINV include: young age, female sex, platinum- or anthracycline-based chemotherapy, nondrinker status, emesis in the earlier cycles of chemoth...

Thalidomide is a sedative drug introduced to European markets on 1 October 1957 after extensive testing on rodent embryos to ensure its safety. Early laboratory tests in rodent populations showed that pregnant rodents could safely use it, so doctors prescribed Thalidomide to treat morning sickness in pregnant women. However, in humans [3] Thalidomide interfered with embryonic and fetal developm...

A few years ago, when officiating as civil surgeon in ODe of the stations of the North-West-Provinces, I was asked to prescribe for a lady whose prevailing and prominent symptom was sickness. It was unceasing. Exaggerated in the morning it continued throughout the day. At night only, when my patient slept, was relief experienced. She had been married a few months. I pronounced her to be pregnan...

Early on the morning of the 7th June last, I visited Mrs G., who supposed herself to be in the fourth month of her first pregnancy. I found she had been slightly ailing for a few days, that on the previous day she had been suffering some abdominal pain, and had repeatedly fainted, and that during the night pain had become constant and severe, with feelings of great tension and sickness. She had...

A simple and rapid UV – Spectrophotometric method was developed and validated for the simultaneous estimation of Doxylamine succinate and Pyridoxine HCl in combined dosage forms. The said combination is used in treating morning sickness associated with pregnancy. For the simultaneous estimation of both drugs, 260 nm and 285 nm were selected as wavelength of analysis. The linearity range was tak...

An antiemetic action is claimed among other uses for acupuncture (ACP), and several antiemetic ACP points are described in textbooks. The most accessible of these is P6, so called because it is on the pericardial meridian. This is also known as Neiguan (Nei-kuan) or G-Jo point no. 10, and the simplest description of locating it is the width of two thumbs above the distal crease on the inner wri...

Nausea and vomiting during pregnancy, or ”morning sickness” are very common, though not well understood. The extreme form, hyperemesis gravidarum can lead to severe complications. We analyzed articles which were published in the last years in this field in MEDLINE. Various etiologies have been suggested, including elevated levels of human chorionic gonadotropin, thyroid hormone or association w...