نتایج جستجو برای: monophosphoryl lipid a

تعداد نتایج: 13481193  

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2004
Michael D Feese Taro Tamada Yoichi Kato Yoshitake Maeda Masako Hirose Yasuko Matsukura Hideki Shigematsu Takanori Muto Atsushi Matsumoto Hiroshi Watarai Kinya Ogami Tomoyuki Tahara Takashi Kato Hiroshi Miyazaki Ryota Kuroki

The cytokine thrombopoietin (TPO), the ligand for the hematopoietic receptor c-Mpl, acts as a primary regulator of megakaryocytopoiesis and platelet production. We have determined the crystal structure of the receptor-binding domain of human TPO (hTPO(163)) to a 2.5-A resolution by complexation with a neutralizing Fab fragment. The backbone structure of hTPO(163) has an antiparallel four-helix ...

2007
Yiorgos Stavrinos Anastasia Veneti

1 Of kits and mole ules Yiorgos Stavrinos∗ and Anastasia Veneti† MPLA, Department of Mathemati s University of Athens GR-15784 Zografou, Gree e 1 Introdu tion This arti le investigates the relation of the logi al systems \Interse tion Logi " and \Interse tion Syn hronous Logi ", abbreviated as IL and ISL, respe tively. They are both introdu ed (the former by Ron hi della Ro a and Roversi [RR01℄...

Journal: :Journal of immunology 2011
Caglar Cekic Carolyn R Casella Duygu Sag Frann Antignano Joseph Kolb Jill Suttles Michael R Hughes Gerald Krystal Thomas C Mitchell

We previously showed that monophosphoryl lipid A (MLA) activates TLR4 in dendritic cells (DCs) in a Toll/IL-1R domain-containing adaptor inducing IFN-β (TRIF)-biased manner: MLA produced from Salmonella minnesota Re595 induced signaling events and expression of gene products that were primarily TRIF dependent, whereas MyD88-dependent signaling was impaired. Moreover, when tested in TRIF-intact/...

Journal: :Molecular medicine reports 2013
Jie Chen Baomu Sun Xiuhua Zhao Dong Liang Junxia Liu Yong Huang Wanke Lei Maomao Chen Weimin Sun

Myeloid-derived suppressor cells (MDSCs) and dendritic cells (DCs) are important in the immune response. In vitro, DCs are derived from myeloid precursors by stimulation with granulocyte macrophage colony‑stimulating factor and interleukin‑4. Previous studies demonstrated that lipopolysaccharide (LPS) in combination with interferon‑γ inhibited DC development but enhanced MDSC functions. Monopho...

Journal: :applied biotechnology reports 0
seyed mohammad gheibi hayat azam sadeghinia shahram nazarian zahra adeli

an adjuvant is a substance that is added to a vaccine to increase the body's immune response to the vaccine. vaccines containing adjuvants are tested for safety in clinical trials before they are licensed for used. the basic action of adjuvants is stimulating adaptive immune responses. adjuvants, recently licensed for human utlization, involve alum squalane oil or water emulsion, influenza viro...

Doaa Mohamed El Demerdash Engy Mohamed Abd El Aziz El Khateeb Mervat Said El Ansary Mervat Wagih Mattar Noha Mohamed El Husseiny Walaa Abd El Fattah Attya Elkak

Background: Generation of monocyte-derived dendritic cells (MDDC) is induced in the presence of GM-CSF and IL-4, and a maturation stimulus is added to the monocyte culture to obtain mature Dendritic Cells (DCs) suitable for therapy. TNF-α is the most common cytokine used for activating DCs and generating mature MDDC either alone or in combination with other cytokines. Objective: To compare effe...

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