Transgenerational epigenetic effects include all processes that have evolved to achieve the nongenetic determination of phenotype. There has been a long-standing interest in this area from evolutionary biologists, who refer to it as non-Mendelian inheritance. Transgenerational epigenetic effects include both the physiological and behavioral (intellectual) transfer of information across generati...

Article history: Received 7 June 2016 Received in revised form 25 July 2016 Accepted 14 August 2016 Available online xxxx We examinedwhether assortative mating for educational attainment (“likemarries like”) can be detected in the genomes of ~1600 UK spouse pairs of European descent. Assortative mating on heritable traits like educational attainment increases the genetic variance and heritabili...

Genetic alterations that lead to loss or changes in tumour-suppressor genes are known to contribute to oral carcinogenesis. Traditional molecular methods to detect such losses have relied on mutation analysis or deletion of the gene. However, epigenetic mechanisms could also contribute to silencing of tumour-suppressor genes. Methylation regions rich in CpG promoters prevent DNA transcription b...

Most of the drugs that are available in the marketplace are administered via the oral route, which is a convenient and cost effective route of administration (Lipinski 1995; Lipinski 2000; Lipinski et al. 2001; Lipinski 2004; Abrahamsson and Lennernas 2005). Thus, oral bioavailability is one of the key considerations for discovery and development of a new chemical entity (NCE). It is well recog...

Prediction of immunogenicity is a substantial barrier in vaccine design. Here, a molecular dynamics approach to assessing the immunogenicity of nanoparticles based on structure is presented. Molecular properties of epitopes on nonenveloped viral particles are quantified via a set of metrics. One such metric, epitope fluctuation (and implied flexibility), is shown to be inversely correlated with...

Laboratory research has found that individuals will consume more calories and make unhealthy food choices when in the presence of an overweight individual, sometimes even regardless of what that individual is eating. This study expanded these laboratory paradigms to the field to examine how weight salience influences eating in the real world. More specifically, we tested the threshold of the ef...

Article history: Received 7 June 2016 Received in revised form 25 July 2016 Accepted 14 August 2016 Available online 29 August 2016 We examinedwhether assortative mating for educational attainment (“likemarries like”) can be detected in the genomes of ~1600 UK spouse pairs of European descent. Assortative mating on heritable traits like educational attainment increases the genetic variance and ...

This conference is the final part of our series of meetings entitled “Genome Architecture in Relation to Disease”. A major part of these meetings is to introduce junior researchers to new topics and new ideas. The previous series focussed on genetics and the use of microarrays for investigating genetic variations and abnormalities. In this series we wanted the topics to evolve from thinking of ...

as recent advancements in biology shows, the molecular machines specially proteins, rna and complex molecules play the main role of the so called cell functionality. it means a very big part of the system biology is concerned with the interactions of such molecular components. drug industries and research institutes are trying hard to better understand the concepts underlying these interactions...