SARS-CoV-2 infectivity is largely determined by the virus Spike protein binding to ACE2 receptor. Meanwhile, marked infection rate differences were reported between populations and individuals. To understand disease dynamic, we developed a computational approach study implications of both RBD mutations polymorphism on stability virus-receptor complex. We used 6LZG PDB RBD/ACE2 3D model, mCSM pl...

Vulvovaginal candidiasis (VVC) is a common disease among women worldwide, therefore, accurate and rapid diagnosis of causative agents based on molecular techniques utilizing amplification of target DNA is highly recomendad for epidemiological purposes and for effective treatment. The aim of this study was to identify clinically Candida species from VVC patients by restriction fragment length po...

Introduction Reelin gene (RELN) codes a large extracellular matrix glycoprotein with serine protease activity and is implicated in the modulation of neuronal signaling, synaptic transmission and plasticity. The reelin plays a fundamental and pivotal role in the development of laminar structures and may be one of the loci contributing to the positive linkage between chromosome 7q and autistic di...

There are about 484 species of Hypericum in the Guttiferae family, which includes Hypericoideae. In Iran, this genus mainly found north, northwest, and center country, they key contributors to floral elements Hyrcanian mountains, Irano-Turanian, Mediterranean regions (such as Zagros). Medicinal, commercial, horticultural values associated with these plants.The genetic diversity was assessed thr...

Relevance and methods . For molecular genetic analysis, samples taken from Romanov sheep in micro-populations of the Yaroslavl region ear by pluck were isolated. Polymorphism genes type 3 protein that inhibits insulin-like growth factor (IGFBP-3), hormone (Gh), calpastatin (CAST) was studied. A selection assessment live weight indicators age periods, depending on genotype, carried out. Results ...

A corollary of the nearly neutral theory of molecular evolution is that the efficiency of natural selection depends on effective population size. In this study, we evaluated the differences in levels of synonymous polymorphism among Drosophila species and showed that these differences can be explained by differences in effective population size. The differences can have implications for the mol...

Genetic diversity among plants sprouted from seven year old clones of mulberry (Morus indica var. S36) was studied using molecular markers such as ISSR and RAPD. The clones showed significant variability in sex expression and the sprouting behavior. These changes were appeared after seven years of rigorous pruning and training (pruned once in every 3-4months). Genetic diversity analysis reveale...

Simple sequence repeats (SSRs) markers are important molecular tools widely used in genetic and genomic research plants. However, the number of SSR developed lentils (Lens culinaris Medik.) so far, which is an economically cool season legume plant, has been very limited. The lack among main factors limiting lentil breeding studies. In this study, 288 clones belonging to enriched libraries with ...

A method for high-resolution genomic fingerprinting of the enteric pathogens Campylobacter jejuni and Campylobacter coli, based on the determination of amplified fragment length polymorphism, is described. The potential of this method for molecular epidemiological studies of these species is evaluated with 50 type, reference, and well-characterised field strains. Amplified fragment length polym...

The development over the past two decades of molecular methods for manipulation of RNA and DNA has afforded molecular virologists the ability to study viral genomes in detail that has heretofore not been possible. There are many molecular techniques now available for typing and subtyping of viruses. The available methods include restriction fragment length polymorphism analysis, Southern blot a...