Detecting intracellular calcium signaling with fluorescent calcium indicator dyes is often coupled with microscopy techniques to follow the activation state of non-excitable cells, including lymphocytes. However, the analysis of global intracellular calcium responses both at the single-cell level and in large ensembles simultaneously has yet to be automated. Here, we present a new software pack...

The lattice conditional independence (LCI) model N(C)<) is defined to be the set of all normal distributions N(O, E) on IR I such that for every pair L, M E 1<, XL and xM are conditionally independent given xLnM (ct , [AP] (1993a)). Here C)< is a ring of subsets (hence a distributive lattice) of the finite index set I such that 0, IE ".K, while for K E 1<, XK is the coordinate projection of x E...

Rapid population growth, and human activities (such as agriculture, industry, transports,...) development have increased vulnerability risk for water resources. Due to the complexity of natural processes and the numerous interactions between hydro-systems and human pressures, water quality is difficult to be quantified. In this context, we present a knowledge discovery process applied to hydrol...

esophagus cancer is the eighth most common cancer worldwide and particularly high in an area extending from the southern border of the caspian sea in iran across central asia to china. since information about this mysterious disease is poor, proteomics may be solving this enigma. altering gene expression in cancer cell is a remarkable indicator can be detected by proteomics techniques and bioin...

This report describes the development of a 7-day infectivity assay for bovine leukemia virus (BLV) which is based on the induction of the major internal virion antigen (a protein with a molecular weight of 25,000) in susceptible indicator monolayer cell cultures. In this assay, the antigen is detected in the indicator cells by the immunoperoxidase antibody technique using a specific rabbit anti...

Animals with compact sensory systems face an encoding problem where a small number of sensory neurons are required to encode information about its surrounding complex environment. Using Caenorhabditis elegans worms as a model, we ask how chemical stimuli are encoded by a small and highly connected sensory system. We first generated a comprehensive library of transgenic worms where each animal e...