For quantitation of the apparent interaction between hu man anti-blood group A (anti-A) antibodies and radioiodinated purified carcinoembryonic antigen (CEA), a radioimmunoassay utilizing molecular sieve chromatography was devised. By the use of this procedure the following observations were made: (a) the majority of human sera that contain anti-A antibodies are capable of binding to radioiodin...

A versatile molecular beacon (MB)-like probe was developed for multiplexed detection based on fluorescence polarization by target-induced allosteric effect and furthermore for resettable logic gate operation.

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Quantitative structure-activity relationship (qSAR) models are used to understand how the structure and activity of chemical compounds relate. In the present study, 37 carboquinone derivatives were evaluated and two different qSAR models were developed using members of the Molecular Descriptors Family (MDF) and the Molecular Descriptors Family on Vertices (MDFV). The usual parameters of regress...

The spread of orf513-bearing class 1 integrons is associated with bla(CTX-M-2) in gram-negative clinical isolates in Argentina, with In35 being the most frequently found integron (74%). Among 65 isolates without bla(CTX-M-2), only one harbored a novel orf513-bearing class 1 integron with the dfrA3b gene. The finding of orf513 not associated with class 1 integrons in two gram-positive strains in...

1Unit of Molecular Biology and Viral Oncology, Department of Experimental Oncology, Istituto Nazionale Tumori IRCCS Fondazione Pascale, 80131 Napoli, Italy 2Department of Microbiology and Immunology, Institute of Human Virology, Baltimore, MD 21201, USA 3Department of Research, International Prevention Research Institute, 69006 Lyon, France 4Department of Pathology, Istituto Nazionale Tumori IR...