1 Institute of Molecular Biology, 55128 Mainz, Germany; 2 University of Manitoba, Cancer Care Manitoba, Winnipeg, R3E 0V9, Canada; 3 Physics Department, University Mainz, 55128 Mainz, Germany; 4 Département de Médecine, CHUS, Université de Sherbrooke, Sherbrooke, J1H 5N4, Canada; 5 Department of Medicine, Jewish General Hospital, McGill University, Montreal, H3T 1E2, Canada; 6 Department of Cel...

Molecular simulations and molecular docking are widely used tools to investigate ligand/target interactions in drug design. High-performance computing (HPC) is boosting both the accuracy predictive power of these approaches. With advent exascale computing, HPC may become standardly applied many design campaigns pharmacological applications. This review discusses how innovative algorithms hardwa...

Meagan A. Jenkins,1* Carl J. Christel,2* Yuxia Jiao,4 Sunday Abiria,4 Kristin Y. Kim,2 Yuriy M. Usachev,3 Gerald J. Obermair,5 Roger J. Colbran,4 and Amy Lee2 1Department of Pharmacology, Emory University, Atlanta, Georgia 30322, Departments of 2Molecular Physiology and Biophysics and 3Pharmacology, University of Iowa, Iowa City, Iowa 52242, 4Department of Molecular Physiology and Biophysics, V...

Research Area: Biophysics Keyword: Biophysics, Nanobio, Nanomachine, Molecular motor 【Purpose and Background of the Research】 Three-dimensional structural information of biological macromolecular machinery is essential for the understanding of mechanisms by which they function, and various methods for structural analyses have been developed to obtain structural information at highest possible r...

Department of Biophysics and Cell Biology, Research Center for Molecular Medicine, University of Debrecen, Debrecen, Hungary, 4032: Z.V., F.P, R.G., G.P Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnologia, Universidad Nacional Autónoma de México, Cuernavaca, Mexico 62210: G.G-B, G.P-A, Y.R., L.D.P. Ecologie, Systématique et Evolution, Université Paris-Sud, F-91405, Orsa...

Department of Physical Chemistry, University of Veszprém, H-8201, Veszprém PO Box 158, Hungary; Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT 84602-5700, USA; Department of Physiology and Developmental Biology and Center for Neuroscience, Brigham Young University, Provo, UT 84602-5700, USA; Department of Physiology and Biophysics, University of Miami School of Me...

a Department of Physiology and Biophysics, University of Miami School of Medicine, P. O. Box 016430, Miami, FL 33101, USA. E-mail: [email protected]; [email protected] b Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT 86402-5700, USA. E-mail: [email protected] c Department of Molecular Biophysics and Physiology, Rush Medical College, 1750 W. Har...

Edward P. Debold, J. P. Schmitt, J. B. Patlak, S. E. Beck, J. R. Moore, J. G. Seidman, C. Seidman, and D. M. Warshaw Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, Vermont; Institute of Pharmacology and Toxicology, University of Würzburg, Würzburg, Germany; Department of Physiology and Biophysics, Boston University School of Medicine, Boston; Department of...

Phototransduction biophysics comprises intracellular molecular reactions and ion fluxes through ion channels on the photoreceptor membrane that converts light into an electrical signal. Phototransduction biophysics serves the purpose of counting photons and integrating these counts to an estimate – a macroscopic voltage response – of light changes from a small area of visual space. To do this t...

a Institut Químic de Sarrià (IQS), Laboratory of Biochemistry, Via Augusta, 390, Barcelona, ES 08017, Spain b Centre Européen de Calcul Atomique et Moléculaire (CECAM), Ecole Polytechnique Fédérale de Lausanne, BCH 4102, Lausanne, CH 1015, Switzerland c Max Planck Institute of Biophysics (MPIBP), Theoretical Molecular Biophysics, Max-von-Laue-Straße, 3, Frankfurt am Main, DE 60438, Germany d Sc...