The Multilateral Initiative on Malaria (MIM) started in 1997 with the aim of giving African scientists an equal voice with Northern scientists in making decisions about malaria research in Africa. Is there a need for MIM today with the large increase in funding for malaria research from governments and foundations? I conclude that MIM is still needed today to support African scientists' investi...

Microdeletions/-duplications in the 22q11 region cause a variety of disorders, including DiGeorge syndrome (DGS; MIM 188400), velocardiofacial syndrome (VCFS; MIM 192430) and cat eye syndrome (CES; MIM 115470). DGS and VCFS have a large clinical overlap and are both caused by deletions of a specific 1-3 Mb region on chromosome 22q11. The overall birth prevalence of 22q11 deletions appears to be...

PURPOSE To evaluate the safety and efficacy of ophthalmic MIM-D3, a tyrosine kinase TrkA receptor agonist, in patients with dry eye. DESIGN A prospective, two-center, randomized, double-masked, placebo-controlled Phase 2 study. METHODS A total of 150 dry eye patients were randomized 1:1:1 to study medication (1% MIM-D3, 5% MIM-D3, or placebo) and dosed twice daily (BID) for 28 days. Key eli...

Hot electron photovoltaics is emerging as a candidate for low cost and ultra thin solar cells. Plasmonic means can be utilized to significantly boost device efficiency. We separately form the tunneling metal-insulator-metal (MIM) junction for electron collection and the plasmon exciting MIM structure on top of each other, which provides high flexibility in plasmonic design and tunneling MIM des...

Surface expression of chemokine receptor CXCR4 is downregulated by MIM, a member of the inverse BAR (I-BAR) domain protein family that recognizes and generates membranes with negative curvatures. Yet, the mechanism for the regulation is unknown. Here, we showed that MIM formed a complex with CXCR4 via binding to E3 ubiquitin ligase AIP4 in response to SDF-1. Overexpression of MIM promoted CXCR4...

Letter Mutations in genes involved in singlestrand break repair (SSBR) have been linked to hereditary cerebellar ataxias. Notably, Ataxia-oculomotor apraxia 1 (AOA1 (MIM: 2 08 920)), Spinocerebellar ataxia with axonal neuropathy 1 (SCAN1 (MIM: 6 07 250)) and Ataxia-oculomotor apraxia 4 (AOA4 (MIM: 616267616267616267)) are associated with mutations in APTX (MIM: 606350), TDP1 (MIM: 607198) and P...

OBJECTIVE To compare the galvanic coupling of conventional and metal injection molded (MIM) brackets with commonly used orthodontic archwires. MATERIALS AND METHODS Six of each type of bracket were suspended in lactic acid along with a sample of orthodontic wire (three nickel-titanium and three copper-nickel-titanium) for 28 days at 37 degrees C. The potential differences between the wires an...

An intelligent transport system open platform integrating the S-band Mobile Interactive Multimedia messaging return channel protocol over satellite (based on Enhanced Spread Spectrum Aloha) has been developed and tested under real environment conditions within the framework of SafeTRIP, an FP7 EU-funded project. This paper presents the first field trials results using the S-band Mobile Interact...

Ionic liquids have attracted a large amount of interest in the past few years. One approach to better understand their peculiar nature and characteristics is through the analysis of their surface properties. Some research has provided novel information on the organization of pure ionic liquids at the vapor-liquid interface; yet, a systematic study on the surface properties of mixtures of ionic ...