We developed a Mitomycin C (MMC)-resistant mouse breast cancer cell subline, R-FM3A, from FM3A parent cells(W-FM3A) by continuous exposure to a concentration of 0.01 microgram/ml MMC for over two months. R-FM3A cells were resistant to MMC and decreased in response to the combined effects of ionizing irradiation and MMC. The resistance to MMC and ionizing irradiation was mediated by a cell-free ...

ABSORPTION AND RELEASE OF MITOMYCIN-C BY “SPONGOSTAN FILM”. LARROSA JMl, FERRER J2, PINILLA 11, POLO VI, SANCHEZ Al, BUENO J’, HONRUBIA FMl. 1 Department of Ophthalmology, “Miguel Set-vet” Hospital. Zaragoza,(Spain) 2 Department of Microbiology, Puroose: To determine the Mitomycin-C (MMC) 0,4 mg./ml. absorption of spumous specimens of “Spongostan Film” (“Sp”) and their liberation rate. Methods:...

AIM To compare 1-year follow-up results of photorefractive keratectomy (PRK) with mitomycin C (MMC) and laser in situ keratomileusis (LASIK) for custom correction of myopia. METHODS Eighty-eight eyes of 44 patients with moderate myopia were randomised to PRK with 0.002% MMC for 1 min in one eye and LASIK in the fellow eye. The 1-year follow-up was evaluated. RESULTS There were no difference...

The effect of chemotherapy drug Mitomycin C (MMC) in combination with recombinant adeno-associated virus II (rAAV2) in cancer therapy was investigated, and the mechanism of MMC affecting rAAV2's bioactivity was also studied. The combination effect was evaluated by the level of GFP and TNF expression in a human glioma cell line, and the mechanism of MMC effects on rAAV mediated gene expression w...

The Matrix Model of Computation (MMC) is a new Turing-complete virtual machine that serves as a formal container for the structural representation and analysis of systems, and finds applications in diverse areas such as Business, Software Engineering and Theoretical Physics. The MMC is a unifying notion in Systemics. It allows uniform, interoperable techniques to be applied to systems in genera...

The antitumor antibiotic mitomycin C (MMC) was studied in vitro using L1210 leukemia and 8226 human myeloma cells. Cytotoxicity was evaluated by colony formation in soft agar, and DMA damage was analyzed using alkaline elution filter assays. The purposes of these studies were: (a) to characterize the time course of MMC-DNA damage; (b) to characterize the type of DNA damage [DNA-DNA interstrand ...

PURPOSE To determine the effects of mitomycin C (MMC) on the expression of chymase and mast cells in the conjunctival scar after trabeculectomy. METHODS Ten eyes of five monkeys were used. Three eyes underwent trabeculectomy with MMC (MMC-treated), four eyes had trabeculectomy without MMC (placebo-treated), and three eyes served as control eyes. Intraocular pressure was measured before and th...

BACKGROUND To find out about the prenatal diagnosis rate of myelomeningocele (MMC) by ultrasound scan in patients referred to the Children's Hospital Medical Center in Tehran, Iran from July 2004 to July 2005. METHODS We included 140 children born with MMC and who were referred for management, surgery and treatment of complications associated with it. The ultrasound reports were examined. Dat...

Mitomycin C (MMC) induced aerobic and hypoxic Cytotoxicity in Chinese hamster V79 cells was studied to evaluate the role of the 1electron versus 2-electron reductive bioactivation. Superoxide dismutase, catatase, and desierai had no protective effects on the aerobic or hypoxic Cytotoxicity of MMC, whereas Tempol and Tempol-H, which are known to interrupt and terminate radical reactions, provide...

background: children with myelomeningocele (mmc) develop a wide variety of hip deformities such as muscle imbalance, contracture, subluxation, and dislocation. various methods and indications have been introduced for treatment of muscle imbalances and other hip problems in patients with mmc but there is no study or meta-analysis to compare the results and complications. this review aims to find...