Background: Mitochondrial DNA (mtDNA) variants have been implicated in keratoconus (KC). The present study aimed to characterize the mtDNA heteroplasmy profile KC and explore association of mitochondrial heteroplasmic levels with KC. Methods: sequencing peripheral blood samples corneal tomography were conducted 300 cases matched controls. number homoplasmic was calculated across genome. Spearma...

The objective of this study was to determine the protective effects of the mitochondrial division inhibitor 1 (Mdivi1) in striatal neurons that stably express mutant Htt (STHDhQ111/Q111) and wild-type (WT) Htt (STHDhQ7/Q7). Using gene expression analysis, biochemical methods, transmission electron microscopy (TEM) and confocal microscopy methods, we studied (i) mitochondrial and synaptic activi...

The mitogenome is an important tool for researching the evolution of metazoan animals. However, until now, only few mitochondrial genes Pseudorhombus pentophthalmus have been reported. Here, we report complete P. pentophthalmus, assembled using Illumina platform. circular 16,684 bp in length, has a bias A+T content 52.78%, encodes 37 (13 protein-coding genes, 22 tRNA 2 rRNA genes), and control ...

In order to perform breeding programs and improve production of native chickens, preserving genetic diversity in different areas of Iran is important due to the reduced available population. Genome sequencing is considered the most functional approach to determine the phylogeny relation between close populations. The aim of the present study was the evaluation of the phylogeny and genetic nucle...