نتایج جستجو برای: mirna target genes

تعداد نتایج: 793481  

Journal: :Biochemical Society transactions 2008
Tamas Dalmay

miRNAs (microRNAs) are recently discovered regulators of gene expression. They target mRNAs that contain partially complementary sites to the miRNA. The level of complementarity is different between target site-miRNA pairs, and finding target genes has proved to be a bigger challenge than expected. The present paper reviews the different approaches to predict and experimentally identify genes t...

2007
Seungil Ro Chanjae Park David Young Kenton M. Sanders Wei Yan

It is believed that depending on the thermodynamic stability of the 5'-strand and the 3'-strand in the stem-loop structure of a precursor microRNA (pre-miRNA), cells preferentially select the less stable one (called the miRNA or guide strand) and destroy the other one (called the miRNA* or passenger strand). However, our expression profiling analyses revealed that both strands could be co-accum...

Journal: :Molecular medicine reports 2016
Tao Wang Bin Wang

The present study integrated microRNA (miRNA) and mRNA expression data obtained from atrial fibrillation (AF) tissues and healthy tissues, in order to identify miRNAs and target genes that may be important in the development of AF. The GSE28954 miRNA expression profile and GSE2240 mRNA gene expression profile were downloaded from the Gene Expression Omnibus. Differentially expressed miRNAs and ...

2009
Feifei Xiao Zhixiang Zuo Guoshuai Cai Shuli Kang Xiaolian Gao Tongbin Li

MicroRNAs (miRNAs) are an important class of small noncoding RNAs capable of regulating other genes' expression. Much progress has been made in computational target prediction of miRNAs in recent years. More than 10 miRNA target prediction programs have been established, yet, the prediction of animal miRNA targets remains a challenging task. We have developed miRecords, an integrated resource f...

2017
Martha L Slattery Jennifer S Herrick John R Stevens Roger K Wolff Lila E Mullany

BACKGROUND Determination of functional pathways regulated by microRNAs (miRNAs), while an essential step in developing therapeutics, is challenging. Some miRNAs have been studied extensively; others have limited information. In this study, we focus on 254 miRNAs previously identified as being associated with colorectal cancer and their database-identified validated target genes. METHODS We us...

2013
Yoshiro Nagata Eigo Shimizu Naoki Hibio Kumiko Ui-Tei

Most of the intracellular endogenous microRNAs (endo-miRNAs) are considered to be saturated in Argonaute (Ago) proteins in the RNA-induced silencing complexes (RISCs). When exogenous miRNAs (exo-miRNAs) are introduced into cells, endo-miRNAs in the RISC may be replaced with exo-miRNAs or exo-miRNAs, and endo-miRNAs might also compete for the position in the newly synthesized RISC with each othe...

Journal: :Aging and disease 2012
Y-h. Taguchi

miRNAs have recently been shown to play a key role in cell senescence, by downregulating target genes. Thus, inference of those miRNAs that critically downregulate target genes is important. However, inference of target gene regulation by miRNAs is difficult and is often achieved simply by investigating significant upregulation during cell senescence. Here, we inferred the regulation of target ...

2009
Ren-Jun Hsu Hsin-Jung Yang Huai-Jen Tsai

We developed a simple, direct and cost-effective approach to search for the most likely target genes of a known microRNA (miRNA) in vitro. We term this method 'labeled miRNA pull-down (LAMP)' assay system. Briefly, the pre-miRNA is labeled with digoxigenin (DIG), mixed with cell extracts and immunoprecipitated by anti-DIG antiserum. When the DIG-labeled miRNA and bound mRNA complex are obtained...

2018
Chengbin Ma Wenying Zhang Qiongwei Wu Yu Liu Chao Wang Guoying Lao Longtao Yang Ping Liu

BACKGROUND The aim of this study is to find the potential miRNA expression signature capable of predicting survival time for cervical squamous cell carcinoma (CSCC) patients. METHODS The expression of 332 miRNAs was measured in 131 (Training cohort) and 130 (Validation cohort) patients with CSCC in the Cancer Genome Atlas (TCGA) data portal. The miRNA expression signature was identified by Co...

Journal: :Frontiers in Oncology 2023

Introduction MicroRNAs may be implicated in the acquisition of drug resistance chronic myeloid leukemia as they regulate expression not only BCR-ABL1 but also genes associated with activation transfer proteins or essential signaling pathways. Methods To understand impact specifically expressed miRNAs and their target genes, we collected peripheral blood mononuclear cells (PBMC) from patients di...

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