نتایج جستجو برای: mirna 7
تعداد نتایج: 663954 فیلتر نتایج به سال:
BACKGROUND The development of effective immunosuppressive regimens has resulted in many cases of successful hand transplantation. Visual skin inspection and histological evaluation are used to assess the rejection of hand transplants, but these methods are largely subjective. In this study, we aimed to determine the potential of microRNAs (miRNAs) as biomarkers for acute rejection in vasculariz...
در گذشته مطالعات متعددی برای پیدا کردن mrna های با بیان متفاوت بین نمونه های نرمال و سرطانی صورت گرفته بود اما تحقیقات گسترده در سالهای اخیر نقش mirna ها را در رشد، مرگ برنامه ریزی شده، تمایز و تکثیر سلولی مشخص کرده و عملکرد مستقیم mirna در سرطان را نیز تأیید می نماید. ساختار mirna ها و نحوه عملکرد آنها نشان می دهد که بسیاری از mirna ها در نمونه های سرطانی به صورت غیرطبیعی بیان می شوند. بنابرای...
During adult neurogenesis, newly formed olfactory bulb (OB) interneurons migrate radially to integrate into specific layers of the OB Despite the importance of this process, the intracellular mechanisms that regulate radial migration remain poorly understood. Here, we find that microRNA (miRNA) let-7 regulates radial migration by modulating autophagy in new-born neurons. Using Argonaute2 immuno...
The H19 lncRNA has been implicated in development and growth control and is associated with human genetic disorders and cancer. Acting as a molecular sponge, H19 inhibits microRNA (miRNA) let-7. Here we report that H19 is significantly decreased in muscle of human subjects with type-2 diabetes and insulin resistant rodents. This decrease leads to increased bioavailability of let-7, causing dimi...
Of the over 200 identified mammalian microRNAs (miRNAs), only a few have known biological activity. To gain a better understanding of the role that miRNAs play in specific cellular pathways, we utilized antisense molecules to inhibit miRNA activity. We used miRNA inhibitors targeting miR-23, 21, 15a, 16 and 19a to test efficacy of antisense molecules in reducing miRNA activity on reporter genes...
Wilms tumour is the most common childhood kidney cancer. Here we report the whole-exome sequencing of 44 Wilms tumours, identifying missense mutations in the microRNA (miRNA)-processing enzymes DROSHA and DICER1, and novel mutations in MYCN, SMARCA4 and ARID1A. Examination of tumour miRNA expression, in vitro processing assays and genomic editing in human cells demonstrates that DICER1 and DROS...
MicroRNAs (miRNAs) are endogenously expressed single-stranded ~21-23 nucleotide RNAs that inhibit gene expression post-transcriptionally by binding imperfectly to elements usually within the 3'untranslated region (3'UTR) of mRNAs. Small interfering RNAs (siRNAs) mediate site-specific cleavage by binding with perfect complementarity to RNA. Here, a cell-based miRNA reporter system was developed ...
Small non-coding RNAs have emerged as key modulators of viral infection. However, with the exception of hepatitis C virus, which requires the liver-specific microRNA (miRNA)-122, the interactions of RNA viruses with host miRNAs remain poorly characterized. Here, we used crosslinking immunoprecipitation (CLIP) of the Argonaute (AGO) proteins to characterize strengths and specificities of miRNA i...
While mature miRNAs have been widely studied, the terminal loop sequences are rarely examined despite regulating both primary and mature miRNA functions. Herein, we attempted to understand the evolutionary pattern of loop sequences by analyzing loops in the let-7 gene family. Compared to the stable miRNA length distributions seen in most metazoans, higher metazoan species exhibit a longer lengt...
ژن های mirna ، بیان ژن های دیگر را با ممانعت از ترجمه و یا تجزیه رونوشت های هدف تنظیم می کنند و بیان غیرعادی آن ها در بدخیمی های مختلف گزارش شده است. ازطرفی، نقش اعضای خانواده گیرنده تیروزین کینازی نوروتروفینی همانند trka در سرطان های مختلف ازجمله در نوروبلاستوما شناخته شده است. در این تحقیق، به منظور شناسایی mirnaهای جدید که ممکن است رونوشت ژن trka را هدف قرار دهند و در پیش آگهی مبتلایان به سر...
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