A bioequivalence study of two verapamil formulations (generic verapamil tablets and Isoptin® tablets) was performed by comparing pharmacokinetic parameters of the parent drug and its major metabolite, norverapamil following a single dose administration of 80 mg verapamil hydrochloride in 22 healthy volunteers according to a randomized, two-period, crossover-design study. Moreover, the feasibili...

A bioequivalence study of two verapamil formulations (generic verapamil tablets and Isoptin® tablets) was performed by comparing pharmacokinetic parameters of the parent drug and its major metabolite, norverapamil following a single dose administration of 80 mg verapamil hydrochloride in 22 healthy volunteers according to a randomized, two-period, crossover-design study. Moreover, the feasibili...

A rapid, sensitive and reproducible HPLC method was developed and validatedfor the analysis of amifostine (AMF) and/or its metabolite, WR-1065 inhuman plasma. The method involves the alkylation of free sulfydryl group with iodoacetic acid followed by derivatization of the drug and its metabolite witho-phthaldialdehyde (OPA) andUVdetection at 340 nm. The derivatized AMF and WR-1065 were eluted i...

a rapid, sensitive and reproducible hplc method was developed and validatedfor the analysis of amifostine (amf) and/or its metabolite, wr-1065 inhuman plasma. the method involves the alkylation of free sulfydryl group with iodoacetic acid followed by derivatization of the drug and its metabolite witho-phthaldialdehyde (opa) anduvdetection at 340 nm. the derivatized amf and wr-1065 were eluted i...

Background: The manipulation of mineral nutrition may affect secondary metabolite production and thus determine the nutritional value food/medicinal plants. Objectives: present study investigated impact nitrogen supply on metabolites physiological parameters Hypericum androsaemum plants grown in sand culture. Methods: Four-week were irrigated by full-strength Hoagland solution (control), nitrat...

(1) Background: soil salinization has become a global problem that restricts agricultural production; thus, there is need to explore the special survival strategies of halophytes in saline–alkali environments. (2) Methods: this study conducted comparative analysis differences metabolites and mineral elements between two indicator plants (Suaeda glauca Suaeda salsa) area. (3) Results: S. salsa l...

imatinib is an orally administered tyrosine kinase inhibitor which inhibits the bcr-abl protein-tyrosine kinase with high selectivity. imatinib is rapidly absorbed from the gut, after oral intake and has an almost absolute bioavailability of 98%. the metabolism of imatinib is mediated by the cytochrome p450 (cyp) isoenzymes in the liver and gut wall. cgp74588 is a major active metabolite of ima...

Abstract Nutrient overload, deficiency, or imbalance are fundamental issues that frequently arises in breeder cows. Malnutrition cattle can cause delayed puberty, an increased risk of pregnancy failure, and infertility. This study aimed to determine the effect nutrient improvement mineral premix supplementation on body weight, average daily gain, blood metabolite profile repeat cattle. Sixteen ...

Background: The majority of studies on soil Aspergillus concern the isolation and characterization of the antimicrobial compounds produced by this organism. Our previous studies indicated an isolated Aspergillus strain soil to be of interest, and this subject is further investigated here. Method:  Soil samples of various locations in Iran were collected. Extract from Aspergillus sp. culture was...