The protective effect of methanolic extract of milk thistle seeds and silymarin against cisplatin-induced renal toxicity in male rats after a single intraperitoneal injection of 3 mg kg cisplatin were studied. Over 5 days, cisplatin-treated rats showed tubular necrosis and elevation in blood urea nitrogen (BUN) and serum creatinine (Scr). Pretreatment of animals with silymarin (50 mg kg) or ext...

Antioxidant properties of ethanol extract of Silybum marianum (milk thistle) seeds was investigated. We have also investigated the protein damage activated by oxidative Fenton reaction and its prevention by Silybum marianum seed extract. Antioxidant potential of Silybum marianum seed ethanol extract was measured using different in vitro methods, such as lipid peroxidation, 1,1-diphenyl-2-picryl...

Milk thistle extract is one of the most commonly used nontraditional therapies, particularly in Germany. Milk thistle is known to contain a number of flavonolignans. We evaluated the effect of silymarin, on the activity of various hepatic drug-metabolizing enzymes in human hepatocyte cultures. Treatment with silymarin (0.1 and 0.25 mM) significantly reduced the activity of CYP3A4 enzyme (by 50 ...

Milk thistle is an important medicinal crop. In this two-year field study, the optimal form [bulk (non-structured), nanoparticles (NPs)] and concentration (0, 50, 100 mg L?1) of chitosan titanium dioxide (TiO2) applications for improving seed yield, as well mineral (N, Mg, Fe, Ti), protein, oil contents were investigated in five ecotypes. Leaf gas exchange, ratio variable to maximum fluorescenc...

Insect herbivory is common, but the conditions under which it reduces the fitness and population size of plants remain poorly understood. We quantified populationlevel impacts of floral herbivory by specialized insects on cobweb thistle (Cirsium occidentale var. occidentale) in a California coastal dune ecosystem, and then compared these demographic effects to those published for Platte thistle...

The results of studies milk thistle productivity depending on soil and climatic conditions, doses timing mineral fertilizers, microelements, growth stimulants, plant protection products are presented. It was revealed that the formation assimilation apparatus biomass is directly related to regime nutrition, treatment seeds, crops with stimulants products. maximum leaf area (48.0 thousand m2/ha) ...

The antifungal activity of ethanol extract of Silybum marianum was investigated invitro against three strains of Rhizoctonia solani at different concentrations (5, 10, 15 and 20%). Bioassay of extract was conducted by poisoned food technique with three replications. The findings showed that strain of R. solani (Eggplant) was susceptible to concentrations of S. marianum more than other strains i...