Oxidant/antioxidant imbalance can occur in obstructive airways disease as a result of ongoing inflammation. Glutathione (GSH) plays a major role in pulmonary antioxidant protection. As an alternative or complement to anti-inflammatory therapy, augmenting antioxidant protection could diminish the effects of inflammation. We describe a case of a patient who had obstructive lung disease responsive...

Glutathione (GSH), a tripeptide (L γ-glutamyl-cysteinyl-glycine) is the major nonprotein thiol found abundantly in eukaryotic cells (1–3). GSH plays a critical role in many metabolic pathways. It acts as a cofactor for intracellular enzymes like the glutathione S-transferases (GST) and glutathione peroxidase; it aids in amino acid transport and is essential for detoxification of xenobiotics and...

Mild therapeutic hypothermia of 32-35°C improved neurologic outcomes in outside hospital cardiac arrest survivor. Furthermore, in experimental studies on infarcted model and pilot studies on conscious patients with acute myocardial infarction, therapeutic hypothermia successfully reduced infarct size and microvascular resistance. Therefore, mild therapeutic hypothermia has received an attention...

The aim of the study was to evaluate the clinical value of multiple brain parameters on monitoring intracranial pressure (ICP) procedures in the therapy of severe traumatic brain injury (sTBI) utilizing mild hypothermia treatment (MHT) alone or a combination strategy with other therapeutic techniques. A total of 62 patients with sTBI (Glasgow Coma Scale score <8) were treated using mild hypothe...

Bangia fuscopurpurea is a widespread intertidal seaweed that commercially cultured in China. This frequently exposed to hyposalinity stress, but little known about the adaptation mechanisms. Ascorbate−glutathione (AsA−GSH) cycle plays important roles many organisms under variety of abiotic including hyposaline stress. In this study, we investigated response key metabolites and enzymes involved ...

Hypothermia may attenuate the progression of ischemia-induced damage in liver. Here, we determined the effects of a brief cycle of hypothermic preconditioning applied before an ischemic/reperfusion (I/R) episode in isolated perfused rat liver (IPRL) on tissue damage and oxidative stress. Rats (male, 200-250 g) were anaesthetised with sodium pentobarbital (60 mg·kg-1 i.p) and underwent laparatom...

Acetaminophen is widely used as a fever and pain reliever drug. However, acetaminophen intoxication was common responsible for thousands of acetaminophen-induced liver injury (AILI) cases worldwide. It understood that glutathione (GSH) depletion causes deposit metabolites which are toxic to cells. N-acetylcysteine (NAC), therapy, has been reported cause side effects such nausea, vomiting, anaph...

PURPOSE To characterize synthesis and transport of glutathione (GSH) by cultured human retinal pigment epithelial (RPE) cells. METHODS Cultured human RPE cells were depleted of glutathione, then incubated with various concentrations of cysteine, glutamate, and glycine or with glutathione. High-performance liquid chromatography was used to measure intracellular glutathione with time. RESULTS...

Mild hypothermia is an established neuroprotectant in the laboratory, showing remarkable and consistent effects across multiple laboratories and models of brain injury. At the clinical level, mild hypothermia has shown benefits in patients who have experienced cardiac arrest and in some pediatric populations experiencing hypoxic brain insults. Its role, however, in stroke therapy has yet to be ...

Tumor microenvironment (TME)-modulated hydrogels were developed for closed-loop management postoperative tumor-associated bone effects responding to the shifted disease states. In early state, can modulate TME of residual tumors by depleting protons and glutathione, release chemotherapeutic agents enhance chemotherapy sensitivity, resulting in reduced metastasis attenuated side effects. late in...